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J-GLOBAL ID：201802280992336450   Reference number：18A0480080

Restoration of mutant hERG stability by inhibition of HDAC6

H DAC6の阻害による変異hERG安定性の回復【Powered by NICT】

Author (10)： Li Peili (Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan) ,  Kurata Yasutaka (Department of Physiology II, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan) ,  Endang Mahati (Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan) ,  Ninomiya Haruaki (Department of Biological Regulation, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan) ,  Higaki Katsumi (Research Center for Bioscience and Technology, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan) ,  Taufiq Fikri (Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan) ,  Morikawa Kumi (Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan) ,  Shirayoshi Yasuaki (Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan) ,  Horie Minoru (Department of Cardiovascular Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan) ,  Hisatome Ichiro (Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University, 86-1, Nishimachi, Yonago, Tottori 683-8503, Japan)
Material： Journal of Molecular and Cellular Cardiology  (J Mol Cell Cardiol)
Volume： 115  Page： 158-169  Publication year： 2018 
JST Material Number： E0538A  ISSN： 0022-2828  CODEN： JMCDAY  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The human ether-a-go-go-relate...

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Thesaurus term： wild type ,  Acetylation ,  immunoprecipitation ,  histone deacetylase ,  human ,  substrate (biochemistry) ,  HEK293 cell ,  Cardiac Myocyte ,  Ubiquitination ,  interaction ,  gene ,  therapy ,  histone deacetylase 6 ,  Lys residue ,  *Genetic Variation ,  bioassay ,  immunoassay
Semi thesaurus term： *variation(biology) , 【Automatic Indexing@JST】

Author keywords (5)： hERG ,  HDAC6 ,  Acetylation ,  Ubiquitination ,  LQT2

JST classification (2)： Transport of cell membrane  (EF04020R) ,  Molecular structure  (EB03020Y)

Terms in the title (5)： 阻害 ,  変異 ,  HERG ,  安定性 ,  回復