Art

J-GLOBAL ID：201802281831074232   Reference number：18A0351512

An innovative method for the preparation of high API-loaded hollow spherical granules for use in controlled-release formulation

徐放性製剤用の高API負荷中空球状か粒の調製のための革新的方法【Powered by NICT】

Author (5)： Asada Takumi (Sumitomo Dainippon Pharma Co., Ltd., 3-45 Kurakakiuchi 1-chome, Ibaraki-shi, Osaka 567-0878, Japan) ,  Kobiki Mitsuaki (Sumitomo Dainippon Pharma Co., Ltd., 3-45 Kurakakiuchi 1-chome, Ibaraki-shi, Osaka 567-0878, Japan) ,  Ochiai Yasushi (Sumitomo Dainippon Pharma Co., Ltd., 3-45 Kurakakiuchi 1-chome, Ibaraki-shi, Osaka 567-0878, Japan) ,  Iwao Yasunori (School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan) ,  Itai Shigeru (School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan)
Material： International Journal of Pharmaceutics  (Int J Pharm)
Volume： 523  Issue： 1  Page： 167-175  Publication year： 2017 
JST Material Number： A0285B  ISSN： 0378-5173  CODEN： IJPHD  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The aim of this study was to p...

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Thesaurus term： macromolecule ,  scanning electron microscope ,  particle size distribution ,  dissolution ,  wetting (humidity) ,  fluidity ,  fluidized bed ,  production technology ,  internal structure ,  mixing equipment ,  polymer ,  granulation ,  X-ray computed tomography ,  *granule (particle) ,  *delayed action preparation ,  *dosage form ,  inspection ,  X-ray inspection ,  radiographic inspection ,  X ray diagnosis ,  nondestructive inspection

Author keywords (6)： Granulation ,  High shear mixer ,  High active pharmaceutical ingredient-loaded granule ,  Hollow spherical particle ,  Controlled release ,  Low cost

JST classification (2)： Basic biopharmacy  (GY01021U) ,  Solid preparations  (GY02030V)

Terms in the title (5)： 徐放性製剤 ,  API ,  中空球 ,  か粒 ,  調製