Art

J-GLOBAL ID：201802284217254206   Reference number：18A1152752

Novel lead structures with both Plasmodium falciparum gametocytocidal and asexual blood stage activity identified from high throughput compound screening

高スループット化合物スクリーニングから同定されたPlasmodium falciparum配偶子細胞および無性血液ステージ活性を有する新規鉛構造【JST・京大機械翻訳】

Author (10)： Sun Wei (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA) ,  Huang Xiuli (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA) ,  Li Hao (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA) ,  Tawa Gregory (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA) ,  Fisher Ethan (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA) ,  Tanaka Takeshi Q. (Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, USA) ,  Shinn Paul (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA) ,  Huang Wenwei (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA) ,  Williamson Kim C. (Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, USA) ,  Zheng Wei (National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, USA)
Material： Malaria Journal (Web)
Volume： 16  Issue： 1  Page： 147  Publication year： 2017 
JST Material Number： U7332A  ISSN： 1475-2875  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background Blocking malaria tr...

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Thesaurus term： similarity ,  cytotoxicity ,  Malaria ,  infection ,  analogical material ,  *gamete ,  antimalarial drug ,  *screening (inspection) ,  Parasites ,  clearance ,  human ,  Cluster Analysis ,  *Plasmodium falciparum ,  growth inhibition ,  *Plasmodium ,  *microorganism ,  *protozoa ,  *Sporozoa
Semi thesaurus term： *Plasmodium , 【Automatic Indexing@JST】

Author keywords (10)： Malaria ,  Transmission blocking ,  Gametocyte ,  Asexual parasite ,  Blood stage ,  Dual-efficacy ,  High throughput screen ,  Cheminformatics ,  Novel structures ,  Dark chemical matter

JST classification (1)： Basic research of antiprotozoan drugs and anthelmintics  (GW17080G)

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Terms in the title (10)： 高スループット ,  スクリーニング ,  同定 ,  Plasmodium ,  配偶子 ,  細胞 ,  血液 ,  ステージ ,  活性 ,  鉛