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J-GLOBAL ID：201802284351523626   Reference number：18A0154871

Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages

Blau症候群の多能性幹細胞モデルは,マクロファージにおけるIFN-γ依存性炎症反応を明らかにする【Powered by NICT】

Author (21)： Takada Sanami (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Takada Sanami (Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan) ,  Kambe Naotomo (Department of Dermatology, Kansai Medical University, Hirakata, Japan) ,  Kawasaki Yuri (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Niwa Akira (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Honda-Ozaki Fumiko (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Kobayashi Kazuki (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Osawa Mitsujiro (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Nagahashi Ayako (Department of Fundamental Cell Technology, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Semi Katsunori (Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Hotta Akitsu (Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Hotta Akitsu (Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan) ,  Asaka Isao (Department of Fundamental Cell Technology, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Yamada Yasuhiro (Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Yamada Yasuhiro (Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan) ,  Nishikomori Ryuta (Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Heike Toshio (Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Matsue Hiroyuki (Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan) ,  Matsue Hiroyuki (Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan) ,  Nakahata Tatsutoshi (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan) ,  Saito Megumu K. (Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan)
Material： Journal of Allergy and Clinical Immunology  (J Allergy Clin Immunol)
Volume： 141  Issue： 1  Page： 339-349.e11  Publication year： 2018 
JST Material Number： A0182B  ISSN： 0091-6749  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Blau syndrome, or early-onset ...

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Thesaurus term： phenotype ,  *macrophage ,  pathophysiology ,  *interferon gamma ,  therapy ,  patient ,  inflammatory cytokine ,  up-regulation ,  variation(biology) ,  NF-kappaB ,  *inflammation
Semi thesaurus term： リガンド ,  NOD2蛋白質 ,  *炎症反応 ,  *Blau症候群 , 【Automatic Indexing@JST】

Author keywords (5)： Blau syndrome ,  nucleotide-binding oligomerization domain 2 ,  nuclear factor κB ,  IFN-γ ,  disease-specific induced pluripotent stem cells

JST classification (2)： Congenital diseases,deformities in general.  (GD03010V) ,  Skin diseases  (GF03000Q)

Terms in the title (7)： Blau症候群 ,  多能性幹細胞 ,  モデル ,  マクロファージ ,  IFN-γ ,  依存性 ,  炎症反応