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J-GLOBAL ID：201802286111692539   Reference number：18A0118695

Identification of core gene networks and hub genes associated with progression of non-alcoholic fatty liver disease by RNA sequencing

RNA配列決定による非アルコール性脂肪肝疾患の進行に関連するコア遺伝子ネットワークとハブ遺伝子の同定

Author (18)： Hotta Kikuko (Department of Medical Innovation, Osaka University Hospital, Suita, Japan) ,  Kikuchi Masataka (Department of Genome Informatics, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Kitamoto Takuya (Pharmacogenomics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kitamoto Takuya (Laboratory of Radiation Safety, National Center for Geriatrics and Gerontology, Obu, Japan) ,  Kitamoto Aya (Pharmacogenomics, Kyoto University Graduate School of Medicine, Kyoto, Japan) ,  Kitamoto Aya (Advanced Research Facilities and Services, Hamamatsu University School of Medicine, Hamamatsu, Japan) ,  Ogawa Yuji (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Honda Yasushi (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Kessoku Takaomi (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Kobayashi Kaori (Department of Genome Informatics, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Kobayashi Kaori (Medical Solutions Division, NEC Corporation, Tokyo, Japan) ,  Yoneda Masato (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Imajo Kento (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Tomeno Wataru (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Nakaya Akihiro (Department of Genome Informatics, Graduate School of Medicine, Osaka University, Suita, Japan) ,  Suzuki Yutaka (Department of Computational Biology and Medical Sciences, The University of Tokyo, Kashiwa, Japan) ,  Saito Satoru (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) ,  Nakajima Atsushi (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan)
Material： Hepatology Research  (Hepatol Res)
Volume： 47  Issue： 13  Page： 1445-1458  Publication year： Dec. 2017 
JST Material Number： W1284A  ISSN： 1386-6346  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： gene network ,...

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Author keywords (5)： DNA methylation ,  fibrosis ,  next-generation RNA sequencing ,  non-alcoholic fatty liver disease ,  weighted gene coexpression network analysis

JST classification (2)： Digestive system diseases  (GH03000W) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (53)：

• Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-31.
• Farrell GC. Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region? J Gastroenterol Hepatol 2003; 18: 124-38.
• Okanoue T, Umemura A, Yasui K, Itoh Y. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in Japan. J Gastroenterol Hepatol 2011; 1: 153-62.
• Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55: 434-8.
• Anstee QM, Day CP. The genetics of NAFLD. Nat Rev Gastroenterol Hepatol 2013; 10: 645-55.

Terms in the title (7)： RNA ,  非アルコール性脂肪肝疾患 ,  コア ,  遺伝子ネットワーク ,  ハブ ,  遺伝子 ,  同定