Art

J-GLOBAL ID：201802286296488591   Reference number：18A0839228

Dual targeting system by supramolecular complex of folate-conjugated methyl-β-cyclodextrin with adamantane-grafted hyaluronic acid for the treatment of colorectal cancer

結腸直腸癌治療のためのアダマンタン-グラフト化ヒアルロン酸と葉酸-共役メチル-β-シクロデキストリンの超分子複合体による二重標的化システム【JST・京大機械翻訳】

Author (7)： Elamin Khaled M. (Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Motoyama Keiichi (Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Higashi Taishi (Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Yamashita Yuki (Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Tokuda Azumi (Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Arima Hidetoshi (Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Arima Hidetoshi (Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto University, Japan)
Material： International Journal of Biological Macromolecules  (Int J Biol Macromol)
Volume： 113  Page： 386-394  Publication year： 2018 
JST Material Number： T0898A  ISSN： 0141-8130  CODEN： IJBMDR  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： In our previous study, we demo...

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Thesaurus term： Cell Death ,  intravenous administration ,  human ,  colonic neoplasm ,  *complex (substance) ,  cytotoxicity ,  antitumor action ,  *supermolecule ,  *therapy ,  antitumor drug ,  CD44 antigen ,  internalization ,  HCT 116 cell ,  *supramolecular complex
Semi thesaurus term： *結腸直腸癌 , 【Automatic Indexing@JST】

Author keywords (6)： Dual targeting ,  Folate receptor ,  CD44 ,  Methyl-β-cyclodextrin ,  Hyaluronic acid ,  Supramolecular complex

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (10)： 結腸直腸癌 ,  治療 ,  アダマンタン ,  グラフト ,  ヒアルロン酸 ,  葉酸 ,  共役 ,  メチル-β-シクロデキストリン ,  分子複合体 ,  二重標的化