Art

J-GLOBAL ID：201802286698507540   Reference number：18A1758326

A Method for Quantification of Tetrahydroglucocorticoid Glucuronides in Human Urine by LC/MS/MS with Isotope-coded Derivatization

同位体コード化誘導体化を用いたLC/MS/MSによるヒト尿中のテトラヒドログルココルチコイドグルクロニドの定量法

Author (7)： MATSUMOTO Takaaki (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  YAMAZAKI Wataru (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  JO Akihiro (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  OGAWA Shoujiro (Faculty of Pharmaceutical Sciences, Tokyo University of Science) ,  MITAMURA Kuniko (Faculty of Pharmaceutical Sciences, Kindai University) ,  IKEGAWA Shigeo (Genmai Koso Co., Ltd.) ,  HIGASHI Tatsuya (Faculty of Pharmaceutical Sciences, Tokyo University of Science)
Material： Analytical Sciences  (Anal Sci)
Volume： 34  Issue： 9  Page： 1003-1009(J-STAGE)  Publication year： 2018 
JST Material Number： G0673B  ISSN： 0910-6340  CODEN： ANSCEN  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *LC-MS analysis ,...
Semi thesaurus term： *LC/ESI-MS/MS ,...

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Author keywords (5)： Tetrahydroglucocorticoid glucuronides ,  isotope-coded derivatization ,  ²H₀/²H₄-1-[(4-dimethylaminophenyl)carbonyl]piperazine ,  LC/ESI-MS/MS ,  urine

JST classification (3)： Physical analysis of organic compounds  (CC03034A) ,  Basic medicine on endocrine system  (GL01020Q) ,  Chromatography and electrophoretic analysis of organic compounds  (CC04034H)

Substance index (15)： DMTMM ,  Allotetrahydrocortisol ,  Allotetrahydrocortisone ,  Tetrahydrocortisol ,  Tetrahydrocortisone ,  methyl (2S,3S,4S,5R,6R)-6-{[(1R,3aS,3bS,5aR,7R,9aS,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-tetradecahydrocyclopenta[a]phenanthren-7-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  methyl (2S,3S,4S,5R,6R)-6-{[(1R,3aS,3bS,5aS,7R,9aS,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-tetradecahydrocyclopenta[a]phenanthren-7-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  methyl (2S,3S,4S,5R,6R)-6-{[(1R,3aS,3bS,5aR,7R,9aS,9bS,11aS)-1-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-10-oxo-dodecahydro-2H-cyclopenta[a]phenanthren-7-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  methyl (2S,3S,4S,5R,6R)-6-{[(1R,3aS,3bS,5aS,7R,9aS,9bS,11aS)-1-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-10-oxo-dodecahydro-2H-cyclopenta[a]phenanthren-7-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  methyl (2S,3S,4S,5R,6R)-6-{2-[(1R,3aS,3bS,5aR,7R,9aS,9bS,10S,11aS)-1,7,10-trihydroxy-9a,11a-dimethyl-tetradecahydrocyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  methyl (2S,3S,4S,5R,6R)-6-{2-[(1R,3aS,3bS,5aS,7R,9aS,9bS,10S,11aS)-1,7,10-trihydroxy-9a,11a-dimethyl-tetradecahydrocyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  methyl (2S,3S,4S,5R,6R)-6-{2-[(1R,3aS,3bS,5aR,7R,9aS,9bS,11aS)-1,7-dihydroxy-9a,11a-dimethyl-10-oxo-dodecahydro-2H-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  methyl (2S,3S,4S,5R,6R)-6-{2-[(1R,3aS,3bS,5aS,7R,9aS,9bS,11aS)-1,7-dihydroxy-9a,11a-dimethyl-10-oxo-dodecahydro-2H-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-3,4,5-trihydroxyoxane-2-carboxylate ,  (2S,3R,4S,5S,6S)-6-{4-[4-(ジメチルアミノ)ベンゾイル]ピペラジン-1-カルボニル}オキサン-2,3,4,5-テトラオール ,  (2S,3R,4S,5S,6S)-6-(4-{4-[ジ(²H₂)メチルアミノ]ベンゾイル}ピペラジン-1-カルボニル)オキサン-2,3,4,5-テトラオール

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Terms in the title (6)： 同位体 ,  コード化 ,  誘導体化 ,  ヒト ,  尿 ,  定量法