Art

J-GLOBAL ID：201802287786058288   Reference number：18A1495892

Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway

敗血症患者からの血清は細胞外ATP依存性インフラマソーム経路の阻害活性を含む

Author (13)： Ho Van Minh (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Hirohashi Nobuyuki (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Kong Weng-Sheng (Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Yun Guo (Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Ota Kohei (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Itai Junji (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Yamaga Satoshi (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Suzuki Kei (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Tanigawa Koichi (Fukushima Global Medical Science Center, Fukushima Medical University) ,  Kanno Masamoto (Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University) ,  Kanno Masamoto (Core Research for Evolutionary Science and Technology, Japan Agency for Medical Research and Development) ,  Kanno Masamoto (Core Development of Advanced Measurement and Analysis Systems, Japan Agency for Medical Research and Development) ,  Shime Nobuaki (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University)
Material： Tohoku Journal of Experimental Medicine  (Tohoku J Exp Med)
Volume： 245  Issue： 3  Page： 193-204(J-STAGE)  Publication year： 2018 
JST Material Number： G0649A  ISSN： 0040-8727  CODEN： TJEMAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： HMG1 protein ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=18A1495892&from=J-GLOBAL&jstjournalNo=G0649A") }}

Author keywords (5)： damage-associated molecular patterns ,  extracellular adenosine triphosphate ,  immunoparalysis ,  innate immune response ,  sepsis

JST classification (2)： Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Blood tests(=hematologic tests)  (GC02050D)

Substance index (3)： adenosine triphosphate ,  Inositol 1,4,5-Trisphosphate ,  Sodium urate

Reference (44)：

• Aswad, F., Kawamura, H. & Dennert, G. (2005) High sensitivity of CD4⁺CD25⁺ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X₇ receptors. J. Immunol., 175, 3075-3083.
• Baron, L., Gombault, A., Fanny, M., Villeret, B., Savigny, F., Guillou, N., Panek, C., Le Bert, M., Lagente, V., Rassendren, F., Riteau, N. & Couillin, I. (2015) The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis., 6, e1629.
• Beavis, P.A., Stagg, J., Darcy, P.K. & Smyth, M.J. (2012) CD73: a potent suppressor of antitumor immune responses. Trends Immunol., 33, 231-237.
• Borsellino, G., Kleinewietfeld, M., Di Mitri, D., Sternjak, A., Diamantini, A., Giometto, R., Höpner, S., Centonze, D., Bernardi, G., Dell’Acqua, M.L., Rossini, P.M., Battistini, L., Rötzschke, O. & Falk, K. (2007) Expression of ectonucleotidase CD39 by Foxp3⁺ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood, 110, 1225-1232.
• Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q.X., Halfmann, R. & Chen, Z.J. (2014) Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell, 156, 1207-1222.

Terms in the title (8)： 敗血症 ,  患者 ,  血清 ,  細胞外ATP ,  依存性 ,  インフラマソーム ,  経路 ,  阻害活性