Art

J-GLOBAL ID：201802288517643438   Reference number：18A0843854

Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS)

異常な核形態はHutchinson-Gilford早老症候群(HGPS)のZMPSTE24欠損魚モデルにおける寿命に依存しない【JST・京大機械翻訳】

Author (17)： Tonoyama Yasuhiro (Branch Laboratory of Gene Medicine, School of Medicine, Keio University, 2 Okubo, Tsukuba, Ibaraki 300-2611, Japan) ,  Shinya Minori (Department of Biology, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8521, Japan) ,  Toyoda Atsushi (Center for Information Biology, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411-8540, Japan) ,  Kitano Takeshi (Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto 860-8555, Japan) ,  Oga Atsunori (Department of Pathology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan) ,  Nishimaki Toshiyuki (Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0674, Japan) ,  Katsumura Takafumi (Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0674, Japan) ,  Oota Hiroki (Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0674, Japan) ,  Wan Miles T. (State Key Laboratory in Marine Pollution, Department of Chemistry, City University of, Hong Kong, China) ,  Yip Bill W.P. (State Key Laboratory in Marine Pollution, Department of Chemistry, City University of, Hong Kong, China) ,  Helen Mok O.L. (State Key Laboratory in Marine Pollution, Department of Chemistry, City University of, Hong Kong, China) ,  Chisada Shinichi (Department of Preventive Medicine and Public Health, Kyorin University, School of Medicine, Tokyo 181-8611, Japan) ,  Deguchi Tomonori (Advanced Genome Design Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Midorigaoka 1-8-31, Ikeda, Osaka, 563-8577, Japan) ,  Au Doris W.T. (State Key Laboratory in Marine Pollution, Department of Chemistry, City University of, Hong Kong, China) ,  Naruse Kiyoshi (Laboratory of Bioresources, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi 444-8585, Japan) ,  Kamei Yasuhiro (Spectrography and Bioimaging Facility, National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi 444-8585, Japan) ,  Taniguchi Yoshihito (Department of Preventive Medicine and Public Health, Kyorin University, School of Medicine, Tokyo 181-8611, Japan)
Material： Comparative Biochemistry and Physiology. C. Toxicology & Pharmacology  (Comparative Biochemistry and Physiology. C. Pharmacology Toxicology & Endocrinology)
Volume： 209  Page： 54-62  Publication year： 2018 
JST Material Number： C0797A  ISSN： 1532-0456  CODEN： CBPCBB  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Lamin is an intermediate prote...

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Thesaurus term： precursor (substance) ,  Oryzias latipes ,  in vitro experiment ,  nuclear membrane ,  somatic cell ,  immunostaining ,  *human ,  gonad ,  fusion protein ,  telomere ,  visualization ,  wild type ,  Phenotype ,  p53 protein ,  Lamins ,  Cyprinodontiformes

Author keywords (10)： Lamin ,  zmpste24 ,  HGPS ,  Medaka ,  Aging ,  Radiosensitivity ,  Nuclear shape ,  TILLING ,  Telomere ,  p53

JST classification (1)： Toxicity of metals and metal compounds  (GZ02022V)

Terms in the title (4)： 早老症候群 ,  欠損 ,  モデル ,  寿命