Art

J-GLOBAL ID：201802291950663673   Reference number：18A1141311

Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer

ペプチドワクチン治療の有効性に対する予測バイオマーカー:進行膵臓癌に関する第II相試験の結果に基づく【JST・京大機械翻訳】

Author (29)： Shindo Yoshitaro (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Hazama Shoichi (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Hazama Shoichi (Department of Translational Research and Developmental Therapeutics against Cancer, Yamaguchi University School of Medicine, Ube, Japan) ,  Suzuki Nobuaki (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Iguchi Haruo (Clinical Research Center, Shikoku Cancer Center, NHO., Matsuyama, Japan) ,  Uesugi Kazuhiro (Clinical Research Center, Shikoku Cancer Center, NHO., Matsuyama, Japan) ,  Tanaka Hiroaki (Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan) ,  Aruga Atsushi (Institute of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Hatori Takashi (Institute of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan) ,  Ishizaki Hidenobu (Department of Surgical Oncology and Regulation of Organ Function, Miyazaki University School of Medicine, Miyazaki, Japan) ,  Umeda Yuzo (Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan) ,  Fujiwara Toshiyoshi (Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Okayama, Japan) ,  Ikemoto Tetsuya (Department of Digestive and Transplant Surgery, Tokushima University Graduate School of Medicine, Tokushima, Japan) ,  Shimada Mitsuo (Department of Digestive and Transplant Surgery, Tokushima University Graduate School of Medicine, Tokushima, Japan) ,  Yoshimatsu Kazuhiko (Department of Surgery, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan) ,  Takenouchi Hiroko (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Matsui Hiroto (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Kanekiyo Shinsuke (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Iida Michihisa (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Koki Yasunobu (Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan) ,  Arima Hideki (Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan) ,  Furukawa Hiroyuki (Department of Pharmacy, Yamaguchi University Hospital, Ube, Japan) ,  Ueno Tomio (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Yoshino Shigefumi (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan) ,  Fujita Tomonobu (Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Kawakami Yutaka (Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan) ,  Nakamura Yusuke (Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, USA) ,  Oka Masaaki (Yamaguchi University, Yamaguchi, Japan) ,  Nagano Hiroaki (Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan)
Material： Journal of Experimental & Clinical Cancer Research (Web)
Volume： 36  Issue： 1  Page： 36  Publication year： 2017 
JST Material Number： U7514A  ISSN： 1756-9966  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Background The purpose of the ...

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Thesaurus term： *therapy ,  Up-Regulation ,  peripheral blood ,  Immunotherapy ,  tumor vaccine ,  Vaccination ,  cytotoxic T cell ,  *vaccine ,  *forecast ,  patient ,  immunoglobulin ,  T cell ,  *peptide ,  *biomarker ,  CD4 positive cell

Author keywords (5)： Pancreatic cancer ,  Peptide vaccine ,  Predictive biomarker ,  PD-1 ,  Tim-3

JST classification (1)： Immunotherapy for tumors  (GE03035B)

Reference (46)：

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• Gut Liver.; Systemic Chemotherapy in Advanced Pancreatic Cancer; HS Lee, SW Park; 10; 2016; 340-347; CR2;
• J Clin Oncol.; Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial; HA Burris, MJ Moore, J Andersen, MR Green, ML Rothenberg, MR Modiano; 15; 1997; 2403-2413; 10.1200/JCO.1997.15.6.2403; CR3;
• J Clin Oncol.; Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group; MJ Moore, D Goldstein, J Hamm, A Figer, JR Hecht, S Gallinger; 25; 2007; 1960-1966; 10.1200/JCO.2006.07.9525; CR4;
• Eur J Cancer.; Development of peripheral neuropathy and its association with survival during treatment with nab-paclitaxel plus gemcitabine for patients with metastatic adenocarcinoma of the pancreas: A subset analysis from a randomised phase III trial (MPACT); D Goldstein, DD Hoff, M Moore, E Greeno, G Tortora, RK Ramanathan; 52; 2016; 85-91; 10.1016/j.ejca.2015.10.017; CR5;

Terms in the title (6)： ペプチドワクチン ,  治療 ,  予測 ,  バイオマーカー ,  進行膵臓癌 ,  第II相試験