Art

J-GLOBAL ID：201802298302774317   Reference number：18A1111737

Widely targeted metabolomics of Alzheimer’s disease postmortem cerebrospinal fluid based on 9-fluorenylmethyl chloroformate derivatized ultra-high performance liquid chromatography tandem mass spectrometry

9-フルオレンイルメチルクロロぎ酸誘導体化超高速液体クロマトグラフィータンデム質量分析に基づくAlzheimer病死後脳脊髄液の広範に標的化されたメタボロミクス【JST・京大機械翻訳】

Author (8)： Muguruma Yoshio (College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan) ,  Tsutsui Haruhito (College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan) ,  Tsutsui Haruhito (ONO Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan) ,  Noda Takumi (College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan) ,  Noda Takumi (ONO Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan) ,  Akatsu Hiroyasu (Department of Medicine for Aging Place, Community Health Care/Community-Based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-0001, Japan) ,  Akatsu Hiroyasu (Department of Neuropathology, Choju Medical Institute, Fukushimura Hospital, Toyohashi 441-8124, Japan) ,  Inoue Koichi (College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan)
Material： Journal of Chromatography B  (Journal of Chromatography B. Analytical Technologies in the Biomedical and Life Sciences)
Volume： 1091  Page： 53-66  Publication year： 2018 
JST Material Number： W0571A  ISSN： 1570-0232  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Confirmed biomarkers of postmo...

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Thesaurus term： metabolite ,  metabolic pathway ,  *cerebrospinal fluid ,  patient ,  metabolism ,  *derivatization ,  principal component analysis ,  *targeting ,  *tandem mass spectrometry ,  *Alzheimer disease ,  biomarker ,  nitrogen heterocyclic compound ,  autacoid ,  primary amine
Semi thesaurus term： プロファイリング ,  健常者 ,  *メタボロミクス , 【Automatic Indexing@JST】

Author keywords (5)： Widely targeted metabolomics ,  Alzheimer’s disease ,  Cerebrospinal fluid ,  9-Fluorenylmethyl chloroformate ,  Ultra-high performance liquid chromatography tandem mass spectrometry

JST classification (1)： Miscellaneous analytical methods of organic compounds  (CC08034J)

Substance index (1)： Histamine

Terms in the title (9)： ぎ酸 ,  誘導体化 ,  超高速液体クロマトグラフィー ,  タンデム質量分析 ,  Alzheimer ,  病死 ,  脳脊髄液 ,  標的化 ,  メタボロミクス