Art

J-GLOBAL ID：201802298998567566   Reference number：18A1199010

Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells

カテコール基はヒト腸細胞におけるクロロゲン酸およびカフェー酸によるPKD-NFκB-IL-8シグナル伝達経路の活性酸素種捕捉媒介抑制を可能にする【JST・京大機械翻訳】

Author (10)： Shin Hee Soon (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan) ,  Shin Hee Soon (Division of Nutrition and Metabolism Research, Korea Food Research Institute, Seongnam-si 13539, Korea) ,  Shin Hee Soon (Department of Food Biotechnology, University of Science and Technology (UST), Daejeon 34113, Korea) ,  Satsu Hideo (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan) ,  Satsu Hideo (Department of Biotechnology, Faculty of Engineering, Maebashi Institute of Technology, Gunma 371-0816, Japan) ,  Bae Min-Jung (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan) ,  Bae Min-Jung (Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 08826, Korea) ,  Totsuka Mamoru (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan) ,  Shimizu Makoto (Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan) ,  Shimizu Makoto (Department of Nutritional Science, Tokyo University of Agriculture, Tokyo 156-8502, Japan)
Material： Nutrients (Web)
Volume： 9  Issue： 2  Page： 165  Publication year： 2017 
JST Material Number： U7255A  ISSN： 2072-6643  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Chlorogenic acid (CHA) and caf...

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Thesaurus term： oxidative stress ,  *NF-kappaB ,  phenolic compound ,  coffee ,  *interleukin 8 ,  light chain ,  *human(primates) ,  translocation(genetics) ,  *capture ,  hydrogen peroxide ,  anti-inflammatory action ,  phosphorylation ,  olefin compound ,  polyphenol ,  unsaturated carboxylic acid ,  alicyclic alcohol ,  carboxylate(ester) ,  hydroxy acid ,  polyol
Semi thesaurus term： p65 , 【Automatic Indexing@JST】

Author keywords (7)： chlorogenic acid ,  caffeic acid ,  interleukine-8 ,  nuclear factor κB ,  protein kinase D ,  reactive oxygen species ,  catechol group

JST classification (3)： Enzyme in general  (EB09010D) ,  Cell physiology in general  (EF02010S) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (2)： Chlorogenic Acid ,  Catechol

Reference (29)：

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• Gao, R.; Fu, Y.; Wei, Z.; Zhou, E.; Li, Y.; Yao, M.; Song, X.; Yang, Z.; Zhang, N. Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressing TLR4-mediated NF-κB signaling pathway. Eur. J. Pharmacol. 2014, 729, 54-58.
• Huang, K.; Liang, X.C.; Zhong, Y.L.; He, W.Y.; Wang, Z. 5-Caffeoylquinic acid decreases diet-induced obesity in rats by modulating PPARα and LXRα transcription. J. Sci. Food Agric. 2015, 95, 1903-1910.
• Jin, S.; Chang, C.; Zhang, L.; Liu, Y.; Huang, X.; Chen, Z. Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice. PLoS ONE 2015, 10, e0120842.
• Liu, Y.J.; Zhou, C.Y.; Qiu, C.H.; Lu, X.M.; Wang, Y.T. Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL 60 cells. Mol. Med. Rep. 2013, 8, 1106-1110.

Terms in the title (10)： カテコール ,  ヒト ,  腸細胞 ,  クロロゲン酸 ,  カフェー酸 ,  NFκB ,  IL-8 ,  シグナル伝達経路 ,  活性酸素種 ,  捕捉