Osawa Takashi

Research theme for competitive and other funds (8)：

2024 - 2027 Cell Membrane Permeation of Oligonucleotides Controlled by Membrane Modulator Molecules
2024 - 2027 細胞膜をゆらす核酸医薬の膜透過機構の総合理解と膜透過学の創成
2024 - 2027 核酸の膜透過を誘導するリン酸部修飾の探索と膜モジュレータ分子の機能評価
2023 - 2026 核酸医薬の活性向上と毒性低減を志向した機能性人工核酸誘導体の効率的合成法の開発
2021 - 2026 RNA標的創薬技術開発/核酸医薬品実用化のための製造及び分析基盤技術開発(核酸医薬品の製造・精製・分析基盤技術の開発)

Show all

Papers (42)：

Tomoaki Hara, Sikun Meng, Yuuya Kasahara, Takashi Osawa, Daisuke Motooka, Hiromichi Sato, Yasuko Arao, Yoshiko Saito, Kana Inoue, Yumiko Hamano, et al. Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects. Molecular Therapy Nucleic Acids. 2025. 102548
Takashi Osawa, Ryota Nakanishi, Keito Uda, So Muramoto, Satoshi Obika. Synthesis and structural analysis of dinucleotides containing 2′,3′-trans-bridged nucleic acids with trans-5,6- or 5,7-fused ring skeleton. Communications Chemistry. 2025. 8. 1. 87
Takashi Osawa. Synthesis of Coumarin-oligonucleiotide Conjugates for Application in DNA-encoded Libraries. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN. 2024. 144. 10. 931-936
Takashi Osawa, Ryosuke Kita, Yuuya Kasahara, Harumi Yamaguma, Taisuke Nakayama, Haruhiko Kamada, Satoshi Obika. In vitro screening of chemically synthesized dipeptide-antisense oligonucleotide conjugates to identify ligand molecules enhancing their activity. Bioorganic & Medicinal Chemistry. 2024. 110. 117814
Qin Ren, Takashi Osawa, Michiaki Tatsuno, Satoshi Obika. THF peroxide as a factor in generating desulphurised products from the solid-phase synthesis of phosphorothioate-modified oligonucleotides. RSC Advances. 2024. 14. 30. 21590-21596

ｍore...

MISC (8)：

大澤昂志. 未来の核酸医薬に貢献できる技術開発を目指して. 生産と技術. 2025. 77. 2. 57-59
Takashi Osawa, Satoshi Obika. Sustainability in Tides Chemistry. Chapter 9: Oligonucleotide Synthesis and State-of-the-Art Drug Discovery. 2024. 194-227
大澤昂志. 修飾核酸の合成. 核酸医薬〜モダリティ・合成・分析・DDSの最新動向〜. 2024. 67-74
大澤昂志, 小比賀聡. アンチセンス核酸およびsiRNA技術. The Lipid. 2024. 35. 1. 14-19
大澤昂志, 小比賀聡. 核酸の分析. 医薬品開発のための分光法. 2022. 197-206

ｍore...

Patents (1)：

Lectures and oral presentations (12)：

The Development of Novel Six-Membered Bridged Nucleic Acids
(10th Annual Meeting of the Oligonucleotide Therapeutics Society 2015)
新規架橋型核酸3'-O,4'-C-エチレンオキシ-5-メチルウリジンの開発
(日本薬学会第135回年会 2015)
Synthesis and Property of a Novel 2’,4’-BNA Analog with 2,6-Dioxabicyclo-[3.2.1]-oct-3-ene Skeleton
(The 40th International Symposium on Nucleic Acid Chemistry 2014)
新規6員環架橋型チミジンを含むオリゴ核酸の合成および機能評価
(第44回複素環化学討論会 2014)
新規六員環架橋型核酸の合成およびその物性評価
(第40回反応と合成の進歩シンポジウム 2014)

ｍore...

Awards (5)：

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page