Rchr
J-GLOBAL ID:201901007964732400
Update date: Apr. 26, 2024
Tsuchiya Hikaru
Tsuchiya Hikaru
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Affiliation and department:
Tokyo Metropolitan Institute of Medical Science
About Tokyo Metropolitan Institute of Medical Science
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Homepage URL (1):
https://kaken.nii.ac.jp/ja/search/?kw=90760132
Research field (2):
Molecular biology
, Functional biochemistry
Research keywords (3):
Protein degradation
, Proteasome
, Ubiquitin
Research theme for competitive and other funds (5):
2023 - 2028 Integrated understanding of proteasomal degradation and the ubiquitin code
2020 - 2024 プロテアソーム結合ユビキチンリガーゼによるタンパク質分解制御
2017 - 2021 Elucidating the role of branched ubiquitin code
2018 - 2020 Elucidation of the proteasome activity by shuttle factors
2015 - 2017 A method for determining ubiquitin chain length in cells
Papers (26):
Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024. 223. 3
Takumi Tsunoda, Miho Riku, Norika Yamada, Hikaru Tsuchiya, Takuya Tomita, Minako Suzuki, Mari Kizuki, Akihito Inoko, Hideaki Ito, Kenta Murotani, et al. ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. EMBO reports. 2022. 23. 2. e51182
佐伯 泰, 土屋 光, 遠藤 彬則. ケモテクノロジーが拓くユビキチンニューフロンティア ケモプロテオミクスによるユビキチン-プロテアソーム系の理解(Understanding the ubiquitin-proteasome system by chemo-proteomics). 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [2S01e-01]
Hikaru Tsuchiya, Akinori Endo, Yasushi Saeki. Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation. Pharmaceuticals (Basel, Switzerland). 2020. 13. 6
Sayaka Yasuda, Hikaru Tsuchiya, Ai Kaiho, Qiang Guo, Ken Ikeuchi, Akinori Endo, Naoko Arai, Fumiaki Ohtake, Shigeo Murata, Toshifumi Inada, et al. Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature. 2020. 578. 7794. 296-300
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MISC (20):
土屋光, 尾勝圭, 田中啓二, 深井周也, 佐伯泰. ユビキチンリガーゼUBE3Aは26Sプロテアソームの負の調節因子である. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
大竹史明, 遠藤彬則, 土屋光, 佐伯泰. Ubiquitin biology revealed by proteomics analysis. 質量分析総合討論会講演要旨集. 2020. 68th
佐伯泰, 土屋光, 遠藤彬則. Understanding the ubiquitin-proteasome system by chemo-proteomics. 日本生化学会大会(Web). 2020. 93rd
土屋光, 佐伯泰. 非定型型ユビキチン鎖の生理機能 細胞内のユビキチン鎖長解析. 生化学. 2020. 92. 1
佐伯泰, 安田さや香, 土屋光. Proteasome phase separation for degradation. 生化学. 2020. 92. 6
more...
Patents (2):
ポリユビキチン化基質の同定方法
ポリユビキチン化基質の同定方法
Professional career (1):
博士 (農学) (東京大学)
Work history (4):
2023/04 - 現在 Tokyo Metropolitan Institute of Medical Science
2020/04 - 2023/09 Tokyo Metropolitan Institute of Medical Science
2019/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science
2015/04 - 2018/03 Tokyo Metropolitan Institute of Medical Science
Awards (1):
2020/02 - 東京都福祉保健局 東京都福祉保健局長賞
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