Rchr
J-GLOBAL ID：201901010950382300   Update date: May. 27, 2024

Murata Asako

ムラタ アサコ | Murata Asako
Affiliation and department：
Kyushu University

About Kyushu University


Job title： Associate professor
Research field  (2)： Chemical biology ,  Biochemistry
Research keywords  (4)： Regulation of RNA structures and functions ,  microRNA (miRNA) ,  Small molecules ,  RNA
Research theme for competitive and other funds  (8)：
  • 2021 - 2025 Development of a method for comprehensively analyzing the interaction between RNA and small molecule and analysis on big data of the RNA-small molecule binding pairs
  • 2021 - 2024 Elucidation of the novel RNA secondary structure induced by a small molecule
  • 2018 - 2021 Small-molecule induced –1 ribosomal frameshifting and its application to the control of protein transport and localization
  • 2015 - 2019 Induction of -1 ribosomal frameshifting by a small molecule and its application to protein transport and localization
  • 2014 - 2018 リピート結合分子をプローブとしたトリヌクレオチドリピート病の化学生物学研究
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Papers (41)：
  • Qingwen Chen, Takeshi Yamada, Asako Murata, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani. A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA. Digital Discovery. 2024. 3. 243-248
  • Qingwen Chen, Takeshi Yamada, Koichi Miyagawa, Asako Murata, Mitsuo Shoji, Kazuhiko Nakatani. A New Small Molecule DoNA Binding to CAG Repeat RNA. Bioorganic & Medicinal Chemistry. 2023. 98. 117580
  • Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania Gendron, Kohji Mori, et al. FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD. eLife. 2023. 12
  • Anisa Ulhusna, Asako Murata, Kazuhiko Nakatani. Inhibitory Effects of Mismatch Binding Molecules on the Repair Reaction of Uracil-Containing DNA. BIOCHEMISTRY. 2022. 61. 2522-2530
  • Yusuke Takashima, Asako Murata, Kei Iida, Ayako Sugai, Masatoshi Hagiwara, Kazuhiko Nakatani. Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding. ACS CHEMICAL BIOLOGY. 2022. 17. 10. 2817-2827
ｍore...
MISC (7)：
  • 村田亜沙子. 次世代を担う女性研究者 マイクロRNA前駆体を標的とする低分子化合物の探索研究. 化学工業. 2016. 67. 4. 275-280
  • 村田亜沙子, 中谷和彦. アカデミア創薬研究の今を知る《注目の標的からの創薬展開》6.顕在化した創薬標的マイクロRNA(miRNA). 実験医学. 2014. 32. 2. 160-165
  • Tips for Target Identification of Bioactive Molecules. 2010. 141-146
  • 佐藤慎一, 村田亜沙子, 上杉志成. ケミカルジェネティクス:化学が教えてくれる生命機能 海洋天然物のケミカルジェネティクス. 細胞工学. 2009. 28. 4. 332-337
  • 村田亜沙子, 上杉志成. iPS細胞誕生後 iPS細胞作製を効率化する化合物. 現代化学. 2008. 452. 37-39
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Patents (1)：
Lectures and oral presentations  (115)：
  • Exploring Target RNA Motifs for Small Molecules: Approach Using Dicer-Mediated Cleavage of Pre-miRNA-Like Library
    (Asia 3 Roundtable on Nucleic Acids 2023 2023)
  • Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs with binding small molecules binding
    (The 50th International Symposium on Nucleic Acids Chemistry (ISNAC2023) 2023)
  • Interaction between a small molecule, NA, and an RNA with the ACG/AUA internal loop
    (The 50th International Symposium on Nucleic Acids Chemistry 2023)
  • Machine learning assisted classification of small molecules targeting CAG repeat DNA
    (The 49th International Symposium on Nucleic Acids Chemistry (ISNAC2022) 2022)
  • Evaluation of the effect of small-molecule binding to mRNA on ribosomal frameshifting in SARS-CoV-2
    (The 49th International Symposium on Nucleic Acids Chemistry (ISNAC2022) 2022)
ｍore...
Education (4)：
  • 2004 - 2006 The University of Tokyo Graduate School of Frontier Sciences Department of Medical Genome Sciences
  • 2003 - 2004 The University of Tokyo Graduate School of Frontier Sciences Department of Integrated Biosciences
  • 2001 - 2003 The University of Tokyo Graduate School of Frontier Sciences Department of Integrated Biosciences
  • 1997 - 2001 University of Tsukuba Second Cluster of Colleges College of Biological Sciences
Professional career (1)：
  • Ph.D. (Life science) (The University of Tokyo)
Work history (8)：
  • 2022/04 - 現在 Kyushu University Associate professor
  • 2019/12 - 2022/03 Osaka University The Institute of Scientific and Industrial Research Associate professor
  • 2012/12 - 2019/11 Osaka University The Institute of Scientific and Industrial Research Assistant professor
  • 2010/06 - 2012/11 Osaka University The Institute of Scientific and Industrial Research Specially appointed research associate
  • 2010/03 - 2010/05 Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS) Research associate
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Association Membership(s) (3)：
The Japana Society of Nucleic Acids Chemistry ,  Japan Society for Chemical Biology ,  The Chemical Society of Japan
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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