Research field (2)：
Hematology and oncology
, Fetal medicine/Pediatrics
Research keywords (4)：
Histiocytosis
, ランゲルハンス細胞組織球症
, 免疫療法
, 小児血液腫瘍
Research theme for competitive and other funds (14)：
2025 - 2029 Molecular Mechanisms of Langerhans Cell Histiocytosis with a Focus on Bone Marrow Measurable Residual Disease
2025 - 2028 Laboratory Ecosystem for Reverse Translational Drug Discovery for Autoimmune Diseases
2024 - 2028 Understanding of the molecular mechanisms of myeloid leukemia associated with Down syndrome and developing molecular target therapy
2024 - 2027 組織球症の標準治療確立を目的としたレジストリおよびバイオレポジトリの構築
2023 - 2026 Establishment of new diagnostic criteria for Langerhans cell histiocytosis-associated neurodegeneration and investigation of underlying pathogenesis
2021 - 2025 Clarification of the mechanism of multistep leukemogenesis of acute megakaryoblastic leukemia associated with Down syndrome and development of the molecular targeted therapy
2021 - 2025 Clarification of the mechanism of multistep leukemogenesis of acute megakaryoblastic leukemia associated with Down syndrome and development of the molecular targeted therapy
2023 - 2025 組織球症に続発する中枢神経変性症の診断・治療エビデンスの創出
2021 - 2024 Molecular pathological classification and identification of molecular target in the non-Langerhans cell histiocytosis
2021 - 2024 Molecular Mechanisms of Bone Marrow Disease in Langerhans cell histiocytosis (LCH)
2018 - 2021 Multistep molecular mechanisms for acute megakaryoblastic leukemia in Down syndrome
2017 - 2020 Cancer immnotherapy to augment antibody dependent cellular cytotoxicity
2014 - 2017 a novel adoptive T cell therapy exerting ADCC for pediatric cancer
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Papers (91)：
Ryo Okuse, Ko Kudo, Tsutomu Toki, Tatsuhiko Tanaka, Ken Furudate, Rika Kanezaki, Akie Kobayashi, Tomohiko Sato, Etsuro Ito, Kiminori Terui. Concurrent Somatic Mutations of the SETBP1 and KRAS Genes in Pediatric AML: A Case Report. Pediatric Blood & Cancer. 2026
Kenichi Sakamoto, Kudo Ko, Takako Yoshioka, Akira Morimoto, Yoko Shioda, Atsuko Nakazawa. Immunohistochemistry-Based Screening for Targetable Kinase Alterations in Non-Langerhans Cell Histiocytosis with Juvenile Xanthogranuloma morphology. Virchows Archiv. 2026
Itaru Hayakawa, Kenichi Sakamoto, Nobuaki Tsuiki, Shiho Yasue, Yoshihiro Gocho, Tomoyuki Utano, Ko Kudo, Yoshiyuki Tsutsumi, Yoko Shioda. Combination Therapy With Dabrafenib and Trametinib for Langerhans Cell Histiocytosis-Associated Neurodegenerative Disease. Pediatric Blood & Cancer. 2026
Rika Kanezaki, Tsutomu Toki, Ryo Okuse, Akie Kobayashi, Moeka Sato, Sayaka Kimura, Ko Kudo, Tomohiko Sato, Tatsuhiko Tanaka, Kenichi Yoshida, et al. Functional impact of a deep intronic variant in the RPS19 gene detected in a case of Diamond-Blackfan anemia syndrome. Haematologica. 2026
田中龍彦, 小林明恵, 佐藤知彦, 工藤耕, 照井君典. A case of megaloblastic anemia following treatment for pneumocystis pneumonia during maintenance therapy for ALL. 日本小児科学会雑誌. 2025. 129. 2
2022/11 - 日本小児血液がん学会 優秀演題賞 BRAFV600E-positive cells as molecular markers of bone marrow disease in pediatric Langerhans cell histiocytosis
2017/11 - plenary paper Detection of Somatic Mutations by PCR-Based Next-Generation Sequencing from Fixed Clinical Specimens in Childhood LC
Association Membership(s) (6)：
Histiocyte Society
, 日本小児科学会
, 日本免疫不全・自己炎症学会
, 日本造血・免疫細胞療法学会
, THE JAPANESE SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY
, THE JAPANESE SOCIETY OF HEMATOLOGY
