Rchr
J-GLOBAL ID：201901014013148348
Update date: Feb. 14, 2024
Keigo Okada
オカダ ケイゴ | Keigo Okada
Affiliation and department：
Job title：
Assistant Professor
Research theme for competitive and other funds (1)：
- FLT3-ITD陽性AMLに対するRSKを標的とした新規治療法の開発
Papers (11)：
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Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, et al. An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Frontiers in immunology. 2021. 12. 618081
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Akiyama H, Umezawa Y, Watanabe D, Okada K, Ishida S, Nogami A, Miura O. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Cancers. 2020. 12. 2
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Nogami A, Yamamoto M, Yamamoto K, Ito M, Umezawa Y, Tohda S, Miura O, Fukuda T. Marginal zone lymphoma-like primary bone marrow lymphoma with long-term pancytopenia preceding diagnosis. Rinsho ketsueki. 2020. 61. 10. 1469-1475
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Ayako Nogami, Keigo Okada, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Osamu Miura. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway. Transl Oncol. 2018. 12. 2. 336-349
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Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa, Osamu Miura. FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Oncotarget. 2018. 9. 10. 8870-8886
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Lectures and oral presentations (17)：
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Inhibition of USP14 induces apoptosis in FLT3-ITD-positive AML cells through upregulation of Nrf-2
(2021)
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A CALR mutation-positive cell line, CALRET, established from post-essential thrombocythemia leukemia
(第82回日本血液学会学術集会 2020)
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FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim
(60th ASH Annual Meeting and Exposition 2019)
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Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells
(59th ASH Annual Meeting & Exposition 2017)
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Deubiquitinase inhibitor WP1130 blocks JAK2-V617F to induce apoptosis in leukemic cells
(The 79th Annual Meeting of the Japanese Society of Hematology 2017)
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Professional career (1)：
Work history (4)：
- 2019/11/01 - 現在 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Internal Medicine Hematology Assistant Professor
- 2019/09/01 - 現在 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Advanced Therapeutic Sciences Hematology Assistant Professor
- 2019/09/01 - 2019/10/31 Tokyo Medical and Dental University Medical Hospital Hospital Departments Department of Internal Medicine Hematology Assistant Professor
- 2014/04/01 - 2018/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Advanced Therapeutic Sciences Hematology Graduate Student
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