Rchr
J-GLOBAL ID：201901014649814062   Update date: Jul. 16, 2024

Hiroki Mano

Hiroki Mano
Research field  (1)： Applied biochemistry
Research theme for competitive and other funds  (2)：
  • 2020 - 2022 Development of in vivo imaging and quantification technique for PPAR gamma ligand using split AkaLuc
  • 2018 - 2020 Development and application of a highly sensitive biosensor to visualize active form of vitamin D in vivo
Papers (25)：
  • Yuichiro Iwai, Ayano Iijima, Satoko Kise, Chika Nagao, Yuto Senda, Kana Yabu, Hiroki Mano, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, et al. Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor. Biomolecules. 2023. 13. 11
  • Takuya Kushioka, Hiroki Mano, Sayuri Matsuoka, Miyu Nishikawa, Kaori Yasuda, Shinichi Ikushiro, Toshiyuki Sakaki. Analysis of vitamin D metabolites in biological samples using a nanoluc-based vitamin D receptor ligand sensing system: NLucVDR. The Journal of steroid biochemistry and molecular biology. 2023. 233. 106367-106367
  • Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Akiko Takeuchi, Hiroki Mano, Shinji Kakuda, Hiroshi Saitoh, Toshiyuki Sakaki, Atsushi Kittaka. Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D3 and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism. The Journal of Organic Chemistry. 2023
  • Fumihiro Kawagoe, Sayuri Mototani, Kaori Yasuda, Hiroki Mano, Akiko Takeuchi, Hiroshi Saitoh, Toshiyuki Sakaki, Atsushi Kittaka. Synthesis of new 26,27-difluoro- and 26,26,27,27-tetrafluoro-25-hydroxyvitamin D<sub>3</sub>: Effects of terminal fluorine atoms on biological activity and half-life. Chemical and Pharmaceutical Bulletin. 2023
  • Hiroki Mano, Takuya Kushioka, Satoko Kise, Chika Nagao, Ayano Iijima, Miyu Nishikawa, Shinichi Ikushiro, Kaori Yasuda, Sayuri Matsuoka, Toshiyuki Sakaki. Development of nanoluciferase-based sensing system that can specifically detect 1α,25-dihydroxyvitamin D in living cells. The Journal of steroid biochemistry and molecular biology. 2022. 227. 106233-106233
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MISC (71)：
  • 岡本侑樹, 真野寛生, 川越文裕, 高野真史, 西川美宇, 生城真一, 橘高敦史, 榊利之, 安田佳織. 変異型ビタミンD受容体に高い親和性を有する新規誘導体の探索. ビタミン. 2024. 98. 4
  • 本谷小佑里, 川越文裕, 安田佳織, 真野寛生, 榊利之, 橘高敦史. 24,24-ジフルオロ-26,27-ジメチルビタミンD3誘導体の合成. ビタミン. 2023. 97. 4
  • 岩井悠一郎, 高橋秀, SHARMA Vanshita, 真野寛生, 川越文裕, 高野真史, 橘高敦史, 中西友子, 佐藤栄人, 榊利之, et al. ヒトCYP24A1発現アデノウイルスベクターを用いたビタミンD誘導体代謝予測系の開発. ビタミン. 2023. 97. 4
  • 川越文裕, 本谷小佑里, 安田佳織, 真野寛生, 榊利之, 橘高敦史. 26,27-ジフルオロ-25-ヒドロキシビタミンD3および26,26,27,27-テトラフルオロ-25-ヒドロキシビタミンD3の合成. ビタミン. 2023. 97. 4
  • 岩井悠一郎, 大下遥己, 真野寛生, 川越文裕, 高野真史, 橘高敦史, 榊利之, 安田佳織. 側鎖にフッ素を有するビタミンD誘導体の代謝およびがん細胞増殖抑制効果. 日本生化学会大会(Web). 2022. 95th
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Patents (2)：
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