Suenaga Yusuke

Affiliation and department：
Job title： Laboratory Head
Homepage URL (1)： https://www.pref.chiba.lg.jp/gan/kenkyujo/departments/et.html

Research field (1)： Tumor biology

Research keywords (12)：分子進化 , 神経内分泌腫瘍 , MYC , 転写 , TLP , p53 , p63 , 遺伝子誕生 , MYCN , 神経芽腫 , NCYM , de novo gene

Research theme for competitive and other funds (22)：

2024 - 2028 子宮内膜発がんにおける多段階発がんとがん多様性創出の分子機構解明
2024 - 2027 NCYMによるオートファジー制御とその胆管発がんへの寄与の解明
2023 - 2026 Elucidation of MYCN/NCYM function in outer radial glial cell
2023 - 2026 Usefulness of ORF dominance as a novel biomarker in cholangiopancreatic cancer
2022 - 2025 オルガノイドを活用したPTEN遺伝子VUSの新規評価法の確立

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Papers (40)：

Nadzifa Nugraheni, Ummi Maryam Zulfin, Beni Lestari, Novia Permata Hapsari, Muthi Ikawati, Rohmad Yudi Utomo, Yusuke Suenaga, Yoshitaka Hippo, Edy Meiyanto. PGV-1 causes disarrangement of spindle microtubule organization resulting in aberrant mitosis in HLF and HuH6 cells associated with altered MYCN status. Advanced Pharmaceutical Bulletin. 2024
Meiyanto, E, Moordiani, M, Novitasari, D, Novitasari, D, Susidarti, R. A, Ikawati, M, Kato, J.-Y, Hippo, Y, Suenaga, Y. Pentagamavunone-1 suppresses MYCN-positive HuH-7 Cancer Cell Growth via Mitotic Arrest in vitro (accepted). Indonesian Journal of Pharmacy. 2024
Assia Mouhand, Kazuma Nakatani, Fumiaki Kono, Yoshitaka Hippo, Tatsuhito Matsuo, Philippe Barthe, Judith Peters, Yusuke Suenaga, Taro Tamada, Christian Roumestand. 1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM. Biomolecular NMR assignments. 2024
Kiyohiro Ando, Yusuke Suenaga, Takehiko Kamijo. DNA Ligase 4 Contributes to Cell Proliferation against DNA-PK Inhibition in MYCN-Amplified Neuroblastoma IMR32 Cells. International Journal of Molecular Sciences. 2023. 24. 10. 9012-9012
Seigi Yamamoto, Fumiaki Kono, Kazuma Nakatani, Miwako Hirose, Katsunori Horii, Yoshitaka Hippo, Taro Tamada, Yusuke Suenaga, Tatsuhito Matsuo. Structural characterization of human de novo protein NCYM and its complex with a newly identified DNA aptamer using atomic force microscopy and small-angle X-ray scattering. Frontiers in oncology. 2023. 13. 1213678-1213678

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MISC (43)：

古樫浩之, 古樫浩之, 中谷一真, 中谷一真, 筆宝義隆, 筆宝義隆, 末永雄介. NCYM promotes tumorigenesis in a mouse cholangiocarcinoma organoid model. 日本がん分子標的治療学会学術集会プログラム・抄録集. 2023. 27th
UTOMO Rohmad Y., UTOMO Rohmad Y., UTOMO Rohmad Y., 末永雄介, 古樫浩之, 古樫浩之, 中谷一真, 中谷一真, 中谷一真, 山本清義, et al. Screening of NCYM-Targeting Drugs using a Cholangiocarcinoma Organoid Model. 日本癌学会学術総会抄録集(Web). 2023. 82nd
巽康年, 増田達哉, 渡部隆義, UTOMO Rohmad Y., UTOMO Rohmad Y., ZULFIN Ummi M., ZULFIN Ummi M., MEIYANTO Edy, 末永雄介, 筆宝義隆, et al. Anti-tumor effect on osteosarcoma cells by curcumin analogs accompanied by histone acetylation inhibition. 日本癌学会学術総会抄録集(Web). 2023. 82nd
ZULFIN Ummi M., ZULFIN Ummi M., 中谷一真, 中谷一真, UTOMO Rohmad Y., UTOMO Rohmad Y., MEIYANTO Edy, MEIYANTO Edy, 筆宝義隆, 末永雄介. Curcumin analogs PGV-1 and CCA-1.1 promote MYCN degradation in MYCN-amplified neuroblastoma cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
末永雄介, 古樫浩之, 中谷一真, リンジェイソン, 古川英作, 加藤護, 河津正人, 筆宝義隆. Global changes in open reading frame dominance of RNAs during cancer evolution. 日本癌学会学術総会抄録集(Web). 2023. 82nd

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Patents (2)：

Books (7)：

Structural and dynamical analysis of disease-related proteins by synchrotron radiation and neutron beam
2024
膵腫瘍の分子多様性~病態の不均一性を紐解く~三次元培養系から見た膵癌の分子多様性
胆と膵 45(7) 2024
Evolutionary biology of tumor initiation and progression
Lausanne: Frontiers Media SA. 2024 ISBN:9782832550991
Molecular Mechanisms and Treatment of MYCN-driven Tumors
Lausanne: Frontiers Media SA 2022
がん生物学イラストレイテッド第2版
羊土社 2019 ISBN:9784758120968

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Lectures and oral presentations (20)：

NCYM in neuroblastoma and cholangiocarcinoma
(The 6th International Seminar on Pharmaceutical Science and Technology (ISPST), in conjunction with The 15th ISCC Annual Meeting 2024 (Plenary talk), Universitas Padjadjaran, Indonesia 2024)
患者由来胆管癌オルガノイドを用いたNCYM標的薬の開発
(日本患者由来がんモデル学会日本人細胞学会合同学術集会2024 2024)
胆管癌オルガノイドを用いたNCYM標的薬の開発
(第10回細胞凝集研究会、佐賀 2024)
生物学科出身のアイデンティティを活かしたがん研究
(進路研究2023 講演会、千葉大学理学部生物学科 2023)
NCYM and ORF dominance in cancer
(The 1st Boso Peninsula Cancer Research Colloquium 2023)

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Education (4)：

2007 - 2010 Chiba University Graduate School of Medical and Pharmaceutical Sciences
2010 - Chiba University Graduate School of Medical and Pharmaceutical Sciences
2005 - 2007 Chiba University Graduate School of Medical and Pharmaceutical Sciences
2001 - 2005 Chiba University Faculty of Science Department of Biology

Work history (9)：

2024/04 - 現在 Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute Laboratory Head
2023/04 - 2024/03 Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute Senior Researcher
2022/04 - 2023/03 千葉県がんセンター研究所発がん制御研究部上席研究員
2018/04 - 2022/03 Chiba Cancer Center
2017/01 - 2020/03 東京理科大学薬学部生命創薬科学科客員准教授

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Committee career (5)：

2021/09 - 現在 Frontiers in Oncology Associate Editor
2021/03 - 現在 International Journal of Molecular Sciences Topics Board Editor
2017/09 - 2023/04 Royal Society of Medicine (London) Overseas Fellow
2020/08 - Frontiers in Pediatrics Guest Editor
2013/09 - The Local Organization Committee of the 6th p63/p73 International Workshop Committee Member

Association Membership(s) (5)：

日本がん分子標的治療学会 , 日本生化学会 , 日本分子生物学会 , 日本癌学会 , Royal Society of Medicine

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