Kondoh Nobuo

Affiliation and department：

Research field (1)： Oral medicine (pathology)

Research theme for competitive and other funds (20)：

2022 - 2025 Modification of the intercellular network of immune cells in tumor microenvironment by sedatives and anesthetics.
2021 - 2024 ハイドロタルサイトの化学的特性を応用した新たな多機能型歯科用セメントの創出
2020 - 2023 口腔扁平上皮癌の悪性化に伴う間葉系および骨髄系間質細胞の免疫制御と調節因子の変化
2020 - 2023 Dental clinical application fo induction odontoblastic differentiation mechanism in Dental Pulp Stem Cells
2018 - 2022 Effect of low-dose / low-dose-rate radiation on systemic immunity of disease model animals

2018 - 2022 Influence of anesthetics on host immunity through cancer microenvironment

2017 - 2020 Mechanisms of immune modulation regulated by factors from OSCC cells on the development of acquiring metastatic potential to regional lymph nodes

2017 - 2020 Effect of immersion in phosphate buffer on the surface charge and protein adsorption properties of titanium dental implant materials

2017 - 2020 Clarification of metastasis development mechanism in oral cancer stem cell

2015 - 2018 The immunomodulatory effects of anesthetics in cancer microenvironment leading to cancer malignancy

2015 - 2018 Antitumor immunities with low dose / low dose rate radiation on murine model with oral squamous cell carcinoma

2014 - 2017 Modulatory effect of fluvastatin upon immune suppression regulated by mesenchymal stromal cells and oral squamous cell carcinoma cells

2014 - 2017 Cellular response to the novel carbonate apatite bone substitute activating bone regeneration

2014 - 2017 Development of biocompatible direct pulp capping cements and the biological effects of the cements on the dental pulp stem cell activities

2013 - 2016 Enhancement of the cell activities on the carbonate apatite bone substitute by the conditioning of the sintering temperature

2012 - 2015 Study for subsets of lymphocyte which take a role on the mechanism that mesenchymal stem cells derived from dental pulp reduce graft versus host disease

2011 - 2013 Basic research for drug discovery: Modulation of early chondrogenesis by the interaction of CCN2 and CCN3

2011 - 2013 Prognosis of oral squamous cell carcinoma patients using gene expression profile and immunological status.

1996 - 1997 Extinction of hematopoietic specific transcription factor genes in cell hybrids between hematopoietic and non-hematopoietic cells

1988 - 1989 リンパ腫におけるc-myc癌遺伝子の発現調節機構

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Papers (185)：

Megumi Ando, Moe Takahashi, Masako Mizuno-Kamiya, Hiroe Morimoto-Ito, Kumiko Ikeno, Kyohei Ueno, Eiji Takayama, Harumi Kawaki, Genjiro Nakamura, Yasunori Muramatsu, et al. Enhanced production of IL-2 from anti-CD3 antibody-stimulated mouse spleen cells by caffeic acid phenethyl ester, a major component of Chinese propolis. Journal of oral biosciences. 2023. 65. 4. 386-394
高橋萌, 神谷真子, 池野久美子, 上野恭平, 梅村直樹, 高山英次, 川木晴美, 中村源次郎, 村松泰徳, 近藤信夫. カフェイン酸フェネチルエステル(CAPE)による、抗CD3抗体刺激マウス脾細胞におけるIL-2産生の促進を介したIL-4およびIL-10の活性化. Journal of Oral Biosciences Supplement. 2023. 2023. [P2-23]
神谷真子, 高山英次, 川木晴美, 梅村直己, 上野恭平, 高橋萌, 村松泰徳, 近藤信夫. マウス刺激脾細胞のインターロイキン-2およびインターロイキン-10産生におよぼすベンゾジアゼピン受容体リガンドの効果. Journal of Oral Biosciences Supplement. 2023. 2023. [P3-22]
ラハマン・シィファ, 鶴田はねみ, 池野久美子, 上野恭平, 梅村直己, 高山英次, 川木晴美, 中村源次郎, 二階堂徹, 近藤信夫. ブラジル産グリーンプロポリス(BGP)によるマウス脾細胞のIL-2産生促進作用に対するカフェイン酸フェネチルエステル(CAPE)の抑制作用. Journal of Oral Biosciences Supplement. 2023. 2023. [P1-13]
安藤恵, 神谷真子, 池野久美子, 上野恭平, 梅村直樹, 高山英次, 川木晴美, 中村源次郎, 近藤信夫. カフェイン酸フェネチルエステル(CAPE)による抗CD3抗体刺激マウス脾細胞のサイトカイン産生調節機構(Regulatory mechanism of cytokine productions from anti CD3 antibody-stimulated mouse spleen cells by caffeic acid phenethyl ester(CAPE)). Journal of Oral Biosciences Supplement. 2022. 2022. 207-207

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MISC (78)：

梅村直己, 上野恭平, 高山英次, 川木晴美, 近藤信夫. Maintenance of cancer stem cell characteristic in oral squamous cell carcinoma cells by the expression of ABCG2 associated with acquired drug resistance. Journal of Oral Biosciences Supplement (Web). 2021. 2021
神谷真子, 高山英次, 川木晴美, 梅村直己, 上野恭平, 高橋萌, 智原栄一, 村松泰徳, 近藤信夫. Effect of midazolam on the IL-10 production in stimulated mouse splenocytes. Journal of Oral Biosciences Supplement (Web). 2021. 2021
安藤恵, 神谷真子, 池野久美子, 上野恭平, 梅村直己, 高山英治, 川木晴美, 中村源次郎, 近藤信夫. Regulation of cytokine production from anti CD3-stimulated mouse spleen cells by Chinese propolis. Journal of Oral Biosciences Supplement (Web). 2021. 2021
巽勇介, 川木晴美, 川木晴美, 上野恭平, 新谷耕平, 梅村直己, 神谷真子, 神谷真子, 高山英次, 堀田正人, et al. Effect of S-PRG filler eluate with different boron concentrations prepared by anion exchange on human dental pulp-derived stem cells. Journal of Oral Biosciences Supplement (Web). 2021. 2021
鶴田はねみ, 神谷真子, 池野久美子, 上野恭平, 梅村直己, 高山英次, 川木晴美, 中村源次郎, 二階堂徹, 近藤信夫. Mechanism of enhanced production of IL-2 from anti CD3-stimulated mouse spleen cells by Brazilian propolis. Journal of Oral Biosciences Supplement (Web). 2021. 2021

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Lectures and oral presentations (159)：

S-PRGフィラーのヒト唾液タンパク質との吸着特性解析
(日本歯科保存学会学術大会プログラムおよび講演抄録集(Web) 2018)
マウス口腔扁平上皮癌細胞由来のIL-1αにより間葉系細胞(10T1/2)に誘導される免疫チェックポイント遺伝子の解析
(Journal of Oral Biosciences Supplement (Web) 2018)
亜鉛置換型ハイドロタルサイト(HDT)セラミックス多孔体の揮発性硫黄化合物(VSC)吸着効果の検討
(Journal of Oral Biosciences Supplement (Web) 2018)
口腔扁平上皮癌細胞由来のIL-1α特異的な間葉系細胞を介した免疫抑制作用の促進
(Journal of Oral Biosciences Supplement (Web) 2018)
麻酔薬が癌組織における免疫抑制環境の形成におよぼす影響
(Journal of Oral Biosciences Supplement (Web) 2018)

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Professional career (1)：

博士(歯学) (北海道大学)

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