Art

J-GLOBAL ID：201902214925926302   Reference number：19A1283845

Revolution in Gene Medicine Therapy and Genome Surgery

遺伝子治療とゲノム外科における革命【JST・京大機械翻訳】

Author (7)： Jiang David J. (Jonas Children’s Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Columbia University, New York, NY 10032, USA) ,  Jiang David J. (Edward S. Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY 10032, USA) ,  Xu Christine L. (Jonas Children’s Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Columbia University, New York, NY 10032, USA) ,  Xu Christine L. (Edward S. Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY 10032, USA) ,  Tsang Stephen H. (Jonas Children’s Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Columbia University, New York, NY 10032, USA) ,  Tsang Stephen H. (Edward S. Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY 10032, USA) ,  Tsang Stephen H. (Department of Pathology & Cell Biology, Stem Cell Initiative (CSCI), Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA)
Material： Genes (Web)
Volume： 9  Issue： 12  Page： 575  Publication year： 2018 
JST Material Number： U7194A  ISSN： 2073-4425  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Recently, there have been revo...

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Thesaurus term： safety ,  clinical trial ,  *surgery ,  vector(genetics) ,  human(primates) ,  *gene therapy ,  endonuclease ,  in vitro experiment ,  *genome ,  retina ,  *therapy
Semi thesaurus term： 最新情報 ,  Cas9 ,  ウイルスベクター ,  免疫特権 , 【Automatic Indexing@JST】

Author keywords (9)： gene therapy ,  gene editing ,  CRISPR/Cas9 ,  Cas12a ,  dual AAV ,  triple AAV ,  clinical trials ,  retina ,  hereditary retinal dystrophies

JST classification (3)： Eye diseases  (GP03000U) ,  Molecular genetics in general  (EC02010J) ,  Eye diagnosis(= ophthalmic diagnosis)  (GP02000N)

Reference (99)：

• Anderson, W.F. September 14, 1990: The Beginning. Hum. Gene Ther. 1990, 1, 371-372.
• Sujirakul, T.; Lin, M.K.; Duong, J.; Wei, Y.; Lopez-Pintado, S.; Tsang, S.H. Multimodal imaging of central retinal disease progression in a 2 year mean follow up of Retinitis Pigmentosa. Am. J. Ophthalmol. 2015, 160, 786-798.
• Abràmoff, M.D.; Garvin, M.K.; Sonka, M. Retinal Imaging and Image Analysis. IEEE Rev. Biomed. Eng. 2010, 3, 169-208.
• Sengillo, J.D.; Justus, S.; Cabral, T.; Tsang, S.H. Correction of Monogenic and Common Retinal Disorders with Gene Therapy. Genes 2017, 8, 53.
• Xu, C.L.; Cho, G.Y.; Sengillo, J.D.; Park, K.S.; Mahajan, V.B.; Tsang, S.H. Translation of CRISPR Genome Surgery to the Bedside for Retinal Diseases. Front. Cell Dev. Biol. 2018, 6, 46.

Terms in the title (3)： 遺伝子治療 ,  ゲノム ,  外科