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J-GLOBAL ID：201902215843837303   Reference number：19A2352497

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors

選択的タンキラーゼ阻害剤としての新規スピロインドリン誘導体の発見【JST・京大機械翻訳】

Author (32)： Shirai Fumiyuki (Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science) ,  Tsumura Takeshi (Medicinal Chemistry Laboratory, Meiji Seika Pharma Co., Ltd.) ,  Yashiroda Yoko (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science) ,  Yuki Hitomi (Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamic Research) ,  Niwa Hideaki (Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamic Research) ,  Sato Shin (Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamic Research) ,  Chikada Tsubasa (Pharmacokinetics and Analysis Laboratory, Meiji Seika Pharma Co., Ltd.) ,  Koda Yasuko (Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science) ,  Washizuka Kenichi (Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science) ,  Yoshimoto Nobuko (Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science) ,  Abe Masako (Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science) ,  Onuki Tetsuo (Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science) ,  Mazaki Yui (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science) ,  Hirama Chizuko (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science) ,  Fukami Takehiro (RIKEN Program for Drug Discovery and Medical Technology Platforms, Saitama, Japan) ,  Watanabe Hirofumi (Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamic Research) ,  Honma Teruki (Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamic Research) ,  Umehara Takashi (Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamic Research) ,  Shirouzu Mikako (Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamic Research) ,  Okue Masayuki (Process Chemistry Laboratory, Manufacturing & Control Research Labs, Meiji Seika Pharma Co., Ltd.) ,  Kano Yuko (Medicinal Chemistry Laboratory, Meiji Seika Pharma Co., Ltd.) ,  Watanabe Takashi (Medicinal Chemistry Laboratory, Meiji Seika Pharma Co., Ltd.) ,  Kitamura Kouichi (Pharmacology Research Laboratory, Meiji Seika Pharma Co., Ltd.) ,  Shitara Eiki (Pharmaceutical Research Division, Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd.) ,  Muramatsu Yukiko (Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Japan) ,  Yoshida Haruka (Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Japan) ,  Mizutani Anna (Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Japan) ,  Seimiya Hiroyuki (Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Japan) ,  Yoshida Minoru (Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science) ,  Yoshida Minoru (Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science) ,  Yoshida Minoru (Department of Biotechnology, The University of Tokyo, Japan) ,  Koyama Hiroo (Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science)
Material： Journal of Medicinal Chemistry  (J Med Chem)
Volume： 62  Issue： 7  Page： 3407-3427  Publication year： 2019 
JST Material Number： D0102A  ISSN： 0022-2623  CODEN： JMCMAR  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The canonical WNT pathway play...

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Thesaurus term： *cellular signal transduction ,  pathogenesis ,  enzyme ,  mouse(animal) ,  heterotrans plantation ,  antitumor drug ,  human(primates)
Semi thesaurus term： 細胞株 ,  結腸直腸癌 ,  Wntシグナル ,  調節因子 ,  Wnt蛋白質 ,  βカテニン ,  *阻害剤 ,  *タンキラーゼ , 【Automatic Indexing@JST】

JST classification (3)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Physicochemical pharmacy in general  (GV01010J) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Terms in the title (4)： タンキラーゼ ,  阻害剤 ,  誘導体 ,  発見