Art

J-GLOBAL ID：201902215852443668   Reference number：19A1475233

Activin E enhances insulin sensitivity and thermogenesis by activating brown/beige adipocytes

アクチビンEは褐色/淡褐色脂肪細胞を活性化することによりインシュリン感受性と熱産生を強化する

Author (6)： SEKIYAMA Kazunari (Faculty of Veterinary Medicine, Kitasato University, School of Veterinary Medicine, Towada, Aomori 034-8628, Japan) ,  SEKIYAMA Kazunari (Laboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya, Tokyo 156-8506, Japan) ,  USHIRO Yuuki (Faculty of Veterinary Medicine, Kitasato University, School of Veterinary Medicine, Towada, Aomori 034-8628, Japan) ,  KURISAKI Akira (Division of Biomedical Sciences, Stem Cell Technology Laboratory, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), Ikoma, Nara 630-0192, Japan) ,  FUNABA Masayuki (Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwakecho, Kyoto 606-8502, Japan) ,  HASHIMOTO Osamu (Faculty of Veterinary Medicine, Kitasato University, School of Veterinary Medicine, Towada, Aomori 034-8628, Japan)
Material： Journal of Veterinary Medical Science (Web)
Volume： 81  Issue： 5  Page： 646-652(J-STAGE)  Publication year： 2019 
JST Material Number： U1094A  ISSN： 1347-7439  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *activin ,...
Semi thesaurus term： beta actin ,...

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Author keywords (5)： INHBE ,  browning/beiging ,  hepatokine ,  thermogenesis ,  UCP1

JST classification (3)： Metabolism and nutrition of lipids  (EJ02034Q) ,  Medical pharmaceuticals for animals  (FE01050B) ,  Biological function  (EB03040U)

Substance index (1)： adenosine triphosphate

Reference (24)：

• 1. Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J. P., De Matteis, R. and Cinti, S. 2010. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am. J. Physiol. Endocrinol. Metab. 298: E1244-E1253.
• 2. Cannon, B. and Nedergaard, J. 2004. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84: 277-359.
• 3. Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y. H., Doria, A., Kolodny, G. M. and Kahn, C. R. 2009. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 360: 1509-1517.
• 4. Cypess, A. M., Chen, Y. C., Sze, C., Wang, K., English, J., Chan, O., Holman, A. R., Tal, I., Palmer, M. R., Kolodny, G. M. and Kahn, C. R. 2012. Cold but not sympathomimetics activates human brown adipose tissue in vivo. Proc. Natl. Acad. Sci. U.S.A. 109: 10001-10005.
• 5. Harms, M. and Seale, P. 2013. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 19: 1252-1263.

Terms in the title (7)： アクチビン ,  褐色 ,  褐色脂肪細胞 ,  活性化 ,  インシュリン感受性 ,  熱産生 ,  強化