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J-GLOBAL ID：201902216743271291   Reference number：19A2670568

α-Aminoisobutyric Acid-Containing Amphipathic Helical Peptide-Cyclic RGD Conjugation as a Potential Drug Delivery System for MicroRNA Replacement Therapy in Vitro

in vitroでのマイクロRNA補充療法のための潜在的ドラッグデリバリーシステムとしてのα-アミノイソ酪酸含有両親媒性螺旋ペプチド-環状RGD結合【JST・京大機械翻訳】

Author (12)： Taniguchi Kohei (Department of General and Gastroenterological Surgery, Osaka Medical College) ,  Taniguchi Kohei (Translational Research Program, Osaka Medical College) ,  Wada Shun-ichi (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, Osaka, Japan) ,  Ito Yuko (Department of General and Gastroenterological Surgery, Osaka Medical College) ,  Hayashi Junsuke (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, Osaka, Japan) ,  Inomata Yosuke (Department of General and Gastroenterological Surgery, Osaka Medical College) ,  Lee Sang-Woong (Department of General and Gastroenterological Surgery, Osaka Medical College) ,  Tanaka Tomohito (Translational Research Program, Osaka Medical College) ,  Komura Kazumasa (Translational Research Program, Osaka Medical College) ,  Akao Yukihiro (United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Japan) ,  Urata Hidehito (Department of Bioorganic Chemistry, Osaka University of Pharmaceutical Sciences, Osaka, Japan) ,  Uchiyama Kazuhisa (Department of General and Gastroenterological Surgery, Osaka Medical College)
Material： Molecular Pharmaceutics
Volume： 16  Issue： 11  Page： 4542-4550  Publication year： 2019 
JST Material Number： W3686A  ISSN： 1543-8384  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Replacement therapy with tumor...

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Thesaurus term： human ,  *therapy ,  *in vitro experiment ,  *peptide ,  antitumor action ,  *drug delivery system ,  oligonucleotide ,  apoptosis induction ,  invasion ,  target gene ,  PBMCs ,  *cyclic ,  *MicroRNAs
Semi thesaurus term： 結腸直腸癌 ,  腫瘍抑制 ,  *補充療法 , 【Automatic Indexing@JST】

Author keywords (5)： drug delivery system ,  replacement therapy ,  cell-penetrating peptide ,  oligonucleotide therapy ,  microRNA

JST classification (2)： Basic research of diagnostic drugs  (GW20010P) ,  Urogenital tumors(=neoplasms)  (GM04000S)

Terms in the title (8)： マイクロRNA ,  補充療法 ,  ドラッグデリバリーシステム ,  α-アミノイソ酪酸 ,  両親媒性 ,  螺旋 ,  ペプチド ,  環状