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J-GLOBAL ID：201902217173267151   Reference number：19A1462914

Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1

ゲノム規模CRISPR/Cas9スクリーニングはマルホルミンA1の細胞毒性に対する感受性因子としてスクアレンエポキシダーゼを明らかにする【JST・京大機械翻訳】

Author (9)： Koizumi Yukio (Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan) ,  Fukushima Jun (Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, 241-438 Kaidobata-Nishi, Shimoshinjo-Nakano, Akita, 010-0195, Japan) ,  Kobayashi Yayoi (Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, 241-438 Kaidobata-Nishi, Shimoshinjo-Nakano, Akita, 010-0195, Japan) ,  Kadowaki Ayumi (Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan) ,  Natsui Miyuki (Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan) ,  Yamaguchi Tomokazu (Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan) ,  Imai Yumiko (Laboratory of Regulation of Intractable Infectious Diseases, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan) ,  Sugiyama Toshihiro (Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan) ,  Kuba Keiji (Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan)
Material： ChemBioChem
Volume： 20  Issue： 12  Page： 1563-1568  Publication year： 2019 
JST Material Number： W1258A  ISSN： 1439-4227  CODEN： CBCHFX  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Malformin A1 (MA1) is a fungus...

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Thesaurus term： *screening(inspection) ,  Eumycetes ,  *cytotoxicity ,  wild type ,  shake out ,  peptide ,  *sensitivity ,  gene
Semi thesaurus term： 阻害剤 ,  候補遺伝子 ,  ハイスループット ,  sgRNA ,  *スクアレンモノオキシゲナーゼ ,  *Cas9 , 【Automatic Indexing@JST】

Author keywords (5)： CRISPR/Cas9 ,  cytotoxicity ,  malformin ,  peptides ,  squalene epoxidase

JST classification (4)： Nucleic acids in general  (EB04010U) ,  Enzyme in general  (EB09010D) ,  Proteins and peptides in general  (EB03010N) ,  Gene manipulation  (EC02050B)

Substance index (1)： Malformin A1

Terms in the title (9)： ゲノム ,  規模 ,  CRISPR ,  Cas9 ,  スクリーニング ,  細胞毒性 ,  感受性 ,  因子 ,  スクアレンエポキシダーゼ