Art

J-GLOBAL ID：201902219055342004   Reference number：19A0727655

A proteomic analysis of serum-derived exosomes in rheumatoid arthritis

関節リウマチにおける血清由来エキソソームのプロテオミクス解析【JST・京大機械翻訳】

Author (13)： Tsuno Hirotaka (Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan) ,  Tsuno Hirotaka (Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan) ,  Arito Mitsumi (Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan) ,  Suematsu Naoya (Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan) ,  Sato Toshiyuki (Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan) ,  Hashimoto Atsushi (Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan) ,  Matsui Toshihiro (Department of Rheumatology, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan) ,  Omoteyama Kazuki (Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan) ,  Sato Masaaki (Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan) ,  Okamoto Kazuki (The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan) ,  Tohma Shigeto (National Hospital Organization Tokyo National Hospital, Tokyo, Japan) ,  Kurokawa Manae S. (Disease Biomarker Analysis and Molecular Regulation, St. Marianna University Graduate School of Medicine, Kawasaki, Japan) ,  Kato Tomohiro (Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan)
Material： BMC Rheumatology (Web)
Volume： 2  Issue： 1  Page： 35  Publication year： 2018 
JST Material Number： U7450A  ISSN： 2520-1026  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： To understand the roles of ser...

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Thesaurus term： donor ,  *Serum ,  mass spectrometry ,  two dimension ,  joint disease ,  osteoarthrosis ,  gel electrophoresis ,  *proteomics ,  *rheumatoid arthritis ,  pathophysiology ,  Proteins ,  two dimensional difference gel electrophoresis ,  *Exosomes
Semi thesaurus term： 健康 ,  プロテオミクス解析 , 【Automatic Indexing@JST】

Author keywords (5)： Exosome ,  Proteomics ,  Rheumatoid arthritis ,  Osteoarthritis ,  Toll like receptor 3

JST classification (4)： Treatment for musculoskeletal diseases in general  (GG05010S) ,  Clinical medicine on musculoskeletal system in general  (GG01030M) ,  Treatment for immunologic diseases,allergic diseases.  (GD04030Y) ,  Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D)

Reference (42)：

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• Nat Cell Biol; Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells; H Valadi, K Ekström, A Bossios, M Sjöstrand, JJ Lee, JO Lötvall; 9; 2007; 654-659; 10.1038/ncb1596; citation_id=CR3
• Semin Immunopathol; Exosomes: immune properties and potential clinical implementations; N Chaput, C Théry; 33; 2011; 419-440; 10.1007/s00281-010-0233-9; citation_id=CR4
• J Immunol Methods; Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry; A Clayton, J Court, H Navabi, M Adams, MD Mason, JA Hobot; 247; 2001; 163-174; 10.1016/S0022-1759(00)00321-5; citation_id=CR5

Terms in the title (4)： 関節リウマチ ,  血清 ,  エキソソーム ,  プロテオミクス解析