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J-GLOBAL ID：201902219087954356   Reference number：19A0173401

High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression

高分子量ヒアルロナンはアグレカナーゼ発現を阻害することにより軟骨を保護する【JST・京大機械翻訳】

Author (11)： Ohtsuki Takashi (Department of Medical Technology, Graduate School of Health Sciences, Okayama University, 2-5-1, Shikata-cho, Okayama, Japan) ,  Asano Keiichi (Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Inagaki Junko (Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Shinaoka Akira (Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Kumagishi-Shinaoka Kanae (Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Cilek Mehmet Z. (Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Hatipoglu Omer F. (Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Oohashi Toshitaka (Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Nishida Keiichiro (Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama, Japan) ,  Komatsubara Issei (Department of General Internal Medicine I, Kawasaki Hospital, Kawasaki Medical School, 2-1-80, Nakasange, Kita-ku, Okayama, Japan) ,  Hirohata Satoshi (Department of Medical Technology, Graduate School of Health Sciences, Okayama University, 2-5-1, Shikata-cho, Okayama, Japan)
Material： Journal of Orthopaedic Research
Volume： 36  Issue： 12  Page： 3247-3255  Publication year： 2018 
JST Material Number： W2653A  ISSN： 0736-0266  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Hyaluronan (HA) is an extracel...

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Thesaurus term： *Cartilage ,  human ,  mRNA ,  metalloproteinase ,  Rattus ,  *hyaluronic acid ,  chondrocyte ,  articular cartilage ,  Extracellular Matrix ,  osteoarthrosis ,  cytokine ,  Aggrecans ,  ADAMTS4 ,  ADAMTS ,  *aggrecanase ,  Myomorpha ,  matrix (base)

Author keywords (4)： aggrecan ,  chondrocyte ,  hyaluronic acid ,  metalloproteinase

JST classification (5)： Gene expression  (EC02040Q) ,  Basic medicine on musculoskeletal system  (GG01020B) ,  Musculoskeletal diseases  (GG03000T) ,  Enzyme physiology  (EJ02020P) ,  Skeletal system  (EJ10030R)

Terms in the title (6)： 高分子量 ,  ヒアルロナン ,  アグレカナーゼ ,  発現 ,  阻害 ,  軟骨