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J-GLOBAL ID：201902220358689734   Reference number：19A2436985

Viral protein R inhibitors from Swertia chirata of Myanmar

ミャンマーのSwertia chirata由来のウイルス蛋白質R阻害剤

Author (8)： Woo So-Yeun (Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan) ,  Win Nwet Nwet (Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan) ,  Noe Oo Wyine Myat (Department of Chemistry, Taungoo University, 08105 Taungoo, Myanmar) ,  Ngwe Hla (Department of Chemistry, University of Yangon, 11041 Yangon, Myanmar) ,  Ito Takuya (Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nisikiori-kita, Tondabayashi, Osaka 584-8540, Japan) ,  Abe Ikuro (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) ,  Abe Ikuro (Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan) ,  Morita Hiroyuki (Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan)
Material： Journal of Bioscience and Bioengineering
Volume： 128  Issue： 4  Page： 445-449  Publication year： Oct. 2019 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： Republic of the Union of Myanmar ,...
Semi thesaurus term： *Swertia chirata ,...

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Author keywords (6)： Swertia chirata ,  TREx-HeLa-Vpr cells ,  Vpr inhibitors ,  Xanthone derivatives ,  Bellidifolin ,  Oleanolic acid

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (6)： Mesuaxanthone A 5-methyl ether ,  Methylswertianin ,  Oleanolic acid ,  Bellidifolin ,  Deccusatin ,  12-Hydroxyoleanolic acid

Reference (44)：

• Stevenson, M.: HIV-1 pathogenesis, Nat. Med., 9, 853-860 (2003).
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• Richter, S. N., Frasson, I., and Palù, G.: Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy? Curr. Med. Chem., 16, 267-286 (2009).
• Dedera, D., Hu, W., Vander Heyden, N., and Ratner, L.: Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells, J. Virol., 63, 3205-3208 (1989).
• Nermut, M. V. and Fassati, A.: Structural analyses of purified human immunodeficiency virus type 1 intracellular reverse transcription complexes, J. Virol., 77, 8196-8206 (2003).

Terms in the title (4)： ミャンマー ,  Swertia ,  ウイルス蛋白質 ,  阻害剤