Art

J-GLOBAL ID：201902223709384252   Reference number：19A2328335

Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction

心臓線維芽細胞におけるDNA損傷応答の活性化および細胞老化は心筋梗塞後の心線維症を制限する

Author (17)： Shibamoto Masato (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Higo Tomoaki (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Naito Atsuhiko T. (Department of Pharmacology, Faculty of Medicine, Toho University) ,  Nakagawa Akito (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Sumida Tomokazu (Department of Neurology, Yale School of Medicine) ,  Okada Katsuki (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Sakai Taku (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Kuramoto Yuki (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Yamaguchi Toshihiro (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo) ,  Ito Masamichi (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo) ,  Masumura Yuki (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Higo Shuichirou (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Lee Jong-Kook (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Lee Jong-Kook (Department of Advanced Cardiovascular Regenerative Medicine, Osaka University Graduate School of Medicine) ,  Hikoso Shungo (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine) ,  Komuro Issei (Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo) ,  Sakata Yasushi (Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine)
Material： International Heart Journal (Web)
Volume： 60  Issue： 4  Page： 944-957(J-STAGE)  Publication year： 2019 
JST Material Number： U1357A  ISSN： 1349-3299  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *fibroblast ,...
Semi thesaurus term： *Cardiac fibroblast ,...

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Author keywords (4)： Fibroblast senescence ,  Juxtacrine ,  Atm ,  Cardiac remodeling

JST classification (2)： Clinical medicine on cardiovascular system in general  (GJ01030V) ,  Cell physiology in general  (EF02010S)

Reference (32)：

• 1. Ambrosy AP, Fonarow GC, Butler J, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol 2014; 63: 1123-33.
• 2. Shinde AV, Frangogiannis NG. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol 2014; 70: 74-82.
• 3. Fan D, Takawale A, Lee J, Kassiri Z. Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease. Fibrogenesis Tissue Repair 2012; 5: 15.
• 4. Talman V, Ruskoaho H. Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration. Cell Tissue Res 2016; 365: 563-81.
• 5. Travers JG, Kamal FA, Robbins J, Yutzey KE, Blaxall BC. Cardiac fibrosis: the fibroblast awakens. Circ Res 2016; 118: 1021-40.

Terms in the title (8)： 心臓線維芽細胞 ,  DNA損傷応答 ,  活性化 ,  細胞老化 ,  心筋梗塞 ,  心 ,  線維症 ,  制限