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J-GLOBAL ID：201902223890013748   Reference number：19A1278468

A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance

ヒトABC輸送体ABCC4遺伝子SNP(rs11568658,559G>T,G187W)はABCC4依存性薬剤耐性を低下させる【JST・京大機械翻訳】

Author (4)： Tsukamoto Megumi (Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan) ,  Yamashita Miho (Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan) ,  Nishi Tsuyoshi (Department of Biomolecular Science and Regulation, Osaka University, Ibaraki, Osaka 567-0047, Japan) ,  Nakagawa Hiroshi (Department of Applied Biological Chemistry, Graduate School of Bioscience and Biotechnology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan)
Material： Cells (Web)
Volume： 8  Issue： 1  Page： 39  Publication year： 2019 
JST Material Number： U7155A  ISSN： 2073-4409  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Broad-spectrum drug resistance...

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Thesaurus term： *gene ,  mRNA ,  single nucleotide polymorphism ,  gene frequency ,  antitumor drug ,  Drug Resistance ,  *ABC transporter ,  recombinase ,  *human ,  effect concentration 50 ,  synonymous substitution ,  overexpression ,  *MRP4 ,  Heredity ,  population genetics ,  *transmembrane protein ,  thiol ,  nitrogen heterocyclic compound ,  sulfide (organic) ,  nitro compound
Semi thesaurus term： *MRP4蛋白質 , 【Automatic Indexing@JST】

Author keywords (4)： ATP-binding cassette (ABC) transporter ,  ABCC4 ,  MRP4 ,  SNP

JST classification (4)： Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Cell physiology in general  (EF02010S) ,  Congenital diseases,deformities in general.  (GD03010V) ,  Function of cell components  (EF03060C)

Substance index (2)： 6-Mercaptopurine ,  Azathioprine

Reference (29)：

• Tamura, A.; Wakabayashi, K.; Onishi, Y.; Takeda, M.; Ikegami, Y.; Sawada, S.; Tsuji, M.; Matsuda, Y.; Ishikawa, T. Re-evaluation and functional classification of non-synonymous single nucleotide polymorphisms of the human ATP-binding cassette transporter ABCG2. Cancer Sci. 2007, 98, 231-239.
• [Green Version] Janke, D.; Mehralivand, S.; Strand, D.; Godtel-Armbrust, U.; Habermeier, A.; Gradhand, U.; Fischer, C.; Toliat, M.R.; Fritz, P.; Zanger, U.M.; et al. 6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4. Hum. Mutat. 2008, 29, 659-669.
• Krishnamurthy, P.; Schwab, M.; Takenaka, K.; Nachagari, D.; Morgan, J.; Leslie, M.; Du, W.; Boyd, K.; Cheok, M.; Nakauchi, H.; et al. Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. Cancer Res. 2008, 68, 4983-4989.
• Nakagawa, H.; Tamura, A.; Wakabayashi, K.; Hoshijima, K.; Komada, M.; Yoshida, T.; Kometani, S.; Matsubara, T.; Mikuriya, K.; Ishikawa, T. Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2. Biochem. J. 2008, 411, 623-631.
• [Green Version] Toyoda, Y.; Sakurai, A.; Mitani, Y.; Nakashima, M.; Yoshiura, K.; Nakagawa, H.; Sakai, Y.; Ota, I.; Lezhava, A.; Hayashizaki, Y.; et al. Earwax, osmidrosis, and breast cancer: Why does one SNP (538G > A) in the human ABC transporter ABCC11 gene determine earwax type? FASEB J. 2009, 23, 2001-2013.

Terms in the title (7)： ヒト ,  ABC輸送体 ,  ABCC4 ,  遺伝子 ,  SNP ,  依存性 ,  薬剤耐性