Art

J-GLOBAL ID：201902224229647546   Reference number：19A1103542

Severe Neutropenia is Associated with Better Clinical Outcomes in Patients with Advanced Pancreatic Cancer Who Receive Modified FOLFIRINOX Therapy

重篤な好中球減少症は,修正FOLFIRINOX療法を受けた進行膵臓癌患者におけるより良い臨床転帰と関連する【JST・京大機械翻訳】

Author (11)： Yamada Yunami (Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan) ,  Fujii Hironori (Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan) ,  Watanabe Daichi (Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan) ,  Kato-Hayashi Hiroko (Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan) ,  Ohata Koichi (Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan) ,  Kobayashi Ryo (Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan) ,  Ishihara Takuma (Gifu University Hospital, Innovative and Clinical Research Promotion Center, Gifu University, Gifu 501-1194, Japan) ,  Uemura Shinya (First Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, Japan) ,  Iwashita Takuji (First Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, Japan) ,  Shimizu Masahito (First Department of Internal Medicine, Gifu University Hospital, Gifu 501-1194, Japan) ,  Suzuki Akio (Department of Pharmacy, Gifu University Hospital, Gifu 501-1194, Japan)
Material： Cancers (Web)
Volume： 10  Issue： 11  Page： 454  Publication year： 2018 
JST Material Number： U7153A  ISSN： 2072-6694  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： While modified FOLFIRINOX ther...

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Thesaurus term： *human(primates) ,  prognosis ,  drug therapy ,  grading(ranking) ,  *neutropenia ,  risk factor ,  man ,  woman ,  lactam ,  lactone ,  carbamate ,  hydroxy compound ,  polynuclear aromatic compound
Semi thesaurus term： エンドポイント ,  全生存期間 ,  有害事象 ,  注射 ,  オキサリプラチン ,  *転帰 ,  *進行膵癌 , 【Automatic Indexing@JST】

Author keywords (6)： modified FOLFIRINOX ,  severe neutropenia ,  overall survival ,  overall response rate ,  time to treatment failure ,  advanced pancreatic cancer

JST classification (5)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Molecular genetics in general  (EC02010J) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Cell physiology in general  (EF02010S) ,  Tumors(=neoplasms)of respiratory system  (GI04000G)

Substance index (1)： Irinotecan

Reference (49)：

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• Matsuda, T.; Ajiki, W.; Marugame, T.; Ioka, A.; Tsukuma, H.; Sobue, T. Research Group of Population-Based Cancer Registries of Japan. Population-based survival of cancer patients diagnosed between 1993 and 1999 in Japan: A chronological and international comparative study. Jpn. J. Clin. Oncol. 2011, 41, 40-51.
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• Okusaka, T.; Ikeda, M.; Fukutomi, A.; Ioka, T.; Furuse, J.; Ohkawa, S.; Isayama, H.; Boku, N. Phase II study of FOLFIRINOX for chemotherapy-naïve Japanese patients with metastatic pancreatic cancer. Cancer Sci. 2014, 105, 1321-1326.
• Mahaseth, H.; Brutcher, E.; Kauh, J.; Hawk, N.; Kim, S.; Chen, Z.; Kooby, D.A.; Maithel, S.K.; Landry, J.; El-Rayes, B.F. Modified FOLFIRINOX regimen with improved safety and maintained efficacy in pancreatic adenocarcinoma. Pancreas 2013, 42, 1311-1315.

Terms in the title (5)： 好中球減少症 ,  FOLFIRINOX療法 ,  進行膵臓癌 ,  患者 ,  臨床転帰