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J-GLOBAL ID：201902224723893997   Reference number：19A0348284

CMT type 2N disease-associated AARS mutant inhibits neurite growth that can be reversed by valproic acid

CMT型2N疾患関連AARS変異体はバルプロ酸により逆転することができる神経突起成長を阻害する

Author (12)： Tatsumi Yuriko (Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan) ,  Matsumoto Naoto (Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan) ,  Iibe Noriko (Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan) ,  Watanabe Natsumi (Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan) ,  Torii Tomohiro (Department of Neuroscience, Baylor College of Medicine, Houston, TX, 77030, USA) ,  Sango Kazunori (Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, 156-8506, Japan) ,  Homma Keiichi (Department of Life Science and Informatics, Maebashi Institute of Technology, Maebashi, Gunma, 371-0816, Japan) ,  Miyamoto Yuki (Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan) ,  Miyamoto Yuki (Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan) ,  Sakagami Hiroyuki (Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, 252-0734, Japan) ,  Yamauchi Junji (Laboratory of Molecular Neuroscience and Neurology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, 192-0392, Japan) ,  Yamauchi Junji (Department of Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo, 157-8535, Japan)
Material： Neuroscience Research  (神経科学)
Volume： 139  Page： 69-78  Publication year： Feb. 2019 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *morphogenesis ,...
Semi thesaurus term： *Charcot-Marie-Tooth病2N ,...

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Author keywords (6)： CMT2N ,  AARS ,  Mutation ,  Localization ,  Process growth ,  Valproic acid

JST classification (3)： Peripheral nervous system  (EJ12020U) ,  Basic neurology  (GN01020W) ,  Enzyme physiology  (EJ02020P)

Substance index (1)： Valproic acid

Terms in the title (8)： CMT ,  疾患 ,  変異体 ,  バルプロ酸 ,  逆転 ,  神経突起 ,  成長 ,  阻害