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J-GLOBAL ID：201902224766644676   Reference number：19A1341696

Generation of C5-desoxy analogs of tetrahydroisoquinoline alkaloids exhibiting potent DNA alkylating ability

強力なDNAアルキル化能を示すテトラヒドロイソキノリンアルカロイドのC5-デオキシ類似体の生成【JST・京大機械翻訳】

Author (5)： Tanifuji Ryo (Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan) ,  Tsukakoshi Kaori (Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan) ,  Ikebukuro Kazunori (Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan) ,  Oikawa Hideaki (Department of Chemistry, Faculty of Science, Hokkaido University, Kita-ku Kita 10 Jo Nishi 8 Chome, Sapporo 060-0810, Japan) ,  Oguri Hiroki (Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 29  Issue： 14  Page： 1807-1811  Publication year： 2019 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： C5-desoxy analogs of tetrahydr...

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Thesaurus term： *DNA ,  interaction ,  chemical synthesis ,  *analogical material ,  enzyme ,  substituent ,  phenolic hydroxyl group ,  *DNA alkylation ,  partial chemical synthesis
Semi thesaurus term： 半合成 , 【Automatic Indexing@JST】

Author keywords (4)： Tetrahydroisoquinoline alkaloids ,  DNA alkylation ,  Saframycins ,  Chemo-enzymatic synthesis

JST classification (3)： Synthesis of drugs  (GV01030F) ,  Basic research of psychotropic drugs  (GW03100Y) ,  Structure-activity relationship of drugs  (GV01050B)

Terms in the title (3)： DNAアルキル化 ,  C5 ,  類似体