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J-GLOBAL ID：201902229476790615   Reference number：19A2482135

Suppression of parotid acinar cell dysfunction by the free radical scavenger 3-methyl-1-phenyl-2-pyrazolin-5-one

フリーラジカルスカベンジャー3-メチル-1-フェニル-2-ピラゾリン-5-オンによる耳下腺腺房細胞の機能障害の抑制

Author (7)： Sakurai Hajime (Division of Cellular Physiology, Nihon University Graduate School of Dentistry at Matsudo) ,  Yokoyama Megumi (Department of Physiology, Nihon University School of Dentistry at Matsudo) ,  Yokoyama Megumi (Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo) ,  Katsumata-Kato Osamu (Department of Physiology, Nihon University School of Dentistry at Matsudo) ,  Katsumata-Kato Osamu (Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo) ,  Fujita-Yoshigaki Junko (Department of Physiology, Nihon University School of Dentistry at Matsudo) ,  Fujita-Yoshigaki Junko (Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo)
Material： Journal of Oral Science  (J Oral Sci)
Volume： 61  Issue： 3  Page： 475-480(J-STAGE)  Publication year： 2019 
JST Material Number： Z0759A  ISSN： 1343-4934  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： cultured cell ,...
Semi thesaurus term： Src kinase

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Author keywords (6)： salivary glands ,  dry mouth ,  hyposalivation ,  oxidative stress ,  calcium signaling ,  exocrine

JST classification (1)： Basic dentistry(= odontology)  (GT01020O)

Substance index (1)： Edaravone

Reference (21)：

• 1. Baum BJ (2000) Prospects for re-engineering salivary glands. Adv Dent Res 14, 84-88.
• 2. Fujita-Yoshigaki J, Tagashira A, Yoshigaki T, Furuyama S, Sugiya H (2005) A primary culture of parotid acinar cells retaining capacity for agonists-induced amylase secretion and generation of new secretory granules. Cell Tissue Res 320, 455-464.
• 3. Qi B, Fujita-Yoshigaki J, Michikawa H, Satoh K, Katsumata O, Sugiya H (2007) Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells. Cell Tissue Res 329, 59-70.
• 4. Fujita-Yoshigaki J, Matsuki-Fukushima M, Sugiya H (2008) Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells. Am J Physiol Cell Physiol 294, C774-785.
• 5. Moriyama S, Yokoyama M, Katsumata-Kato O (2015) Enhancement of Src family kinase activity is essential for p38 MAP kinase-mediated dedifferentiation signal of parotid acinar cells. Int J Oral-Med Sci 14, 33-40.

Terms in the title (6)： フリーラジカルスカベンジャー ,  フェニル ,  2-ピラゾリン-5-オン ,  耳下腺 ,  腺房細胞 ,  機能障害