Art

J-GLOBAL ID：201902231117099735   Reference number：19A1654304

Verification of pharmacogenomics-based algorithms to predict warfarin maintenance dose using registered data of Japanese patients

日本人患者の登録データを用いたワルファリン維持用量を予測するための薬理ゲノミクスに基づくアルゴリズムの検証【JST・京大機械翻訳】

Author (17)： Sasano Maki (Clinical Pharmacology and Therapeutics Project, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Ohno Masako (School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan) ,  Fukuda Yuya (Advanced Research of Medical and Pharmaceutical Sciences , Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Nonen Shinpei (School of Pharmacy, Hyogo University of Health Sciences, Kobe, Hyogo, Japan) ,  Hirobe Sachiko (Clinical Pharmacology and Therapeutics Project, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Hirobe Sachiko (Advanced Research of Medical and Pharmaceutical Sciences , Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Maeda Shinichiro (Clinical Pharmacology and Therapeutics Project, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Maeda Shinichiro (Advanced Research of Medical and Pharmaceutical Sciences , Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Miwa Yoshihiro (Department of Pharmacy, Osaka University Hospital, Osaka, Japan) ,  Yokoyama Junya (Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Nakayama Hiroyuki (Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Miyagawa Shigeru (Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Sawa Yoshiki (Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan) ,  Fujio Yasushi (Clinical Pharmacology and Therapeutics Project, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Fujio Yasushi (Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Maeda Makiko (Clinical Pharmacology and Therapeutics Project, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan) ,  Maeda Makiko (Advanced Research of Medical and Pharmaceutical Sciences , Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan)
Material： European Journal of Clinical Pharmacology
Volume： 75  Issue： 7  Page： 901-911  Publication year： 2019 
JST Material Number： A0208A  ISSN： 0031-6970  CODEN： EJCPAS  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Large inter-individual differe...

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Thesaurus term： *human(primates) ,  *forecast ,  cytochrome P450 ,  human race specificity ,  *dose ,  body weight ,  gene ,  genotype ,  *algorithm ,  polymerase chain reaction ,  Africa ,  lactone ,  polynuclear aromatic compound ,  hydroxy ketone
Semi thesaurus term： 被験者 ,  性別 ,  *ゲノム薬理学 ,  *日本人 , 【Automatic Indexing@JST】

Author keywords (5)： Warfarin ,  Algorithm ,  VKORC1 ,  CYP2C9 ,  CYP4F2

JST classification (3)： Population genetics  (EC01040J) ,  Clinical biopharmacy  (GY01022L) ,  Enzyme physiology  (EJ02020P)

Substance index (1)： Warfarin

Terms in the title (9)： 日本人 ,  患者 ,  登録データ ,  ワルファリン ,  用量 ,  予測 ,  薬理ゲノミクス ,  アルゴリズム ,  検証