Art

J-GLOBAL ID：201902231905162263   Reference number：19A0800048

Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trial

静脈内免疫グロブリン(Kaica)に対する非反応のリスク増加のために予測される川崎病患者における冠動脈異常予防のための免疫グロブリン+シクロスポリンによる一次治療の有効性:無作為化対照,オープンラベル,盲検エンドポイント,第3相試験【JST・京大機械翻訳】

Author (36)： Hamada Hiromichi (Graduate School of Medicine, Chiba University, Chiba, Japan) ,  Hamada Hiromichi (Department of Pediatrics, Yachiyo Medical Center, Tokyo Women’s Medical University, Chiba, Japan) ,  Suzuki Hiroyuki (Department of Pediatrics, Wakayama Medical University of Medicine, Wakayama, Japan) ,  Onouchi Yoshihiro (Department of Public Health, Chiba University, Chiba, Japan) ,  Ebata Ryota (Department of Pediatrics, Chiba University, Chiba, Japan) ,  Terai Masaru (Department of Pediatrics, Yachiyo Medical Center, Tokyo Women’s Medical University, Chiba, Japan) ,  Fuse Shigeto (Department of Pediatrics, NTT Sapporo Medical Center, Sapporo, Japan) ,  Okajima Yoshitomo (Department of Pediatrics, Chiba Cardiovascular Center, Chiba, Japan) ,  Kurotobi Shunji (Oriono Clinic, Sakai, Japan) ,  Hirai Katsuki (Department of Pediatrics, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan) ,  Soga Takashi (Department of Pediatrics, Showa University Northern Yokohama Hospital, Yokohama, Japan) ,  Ishiguchi Yukiko (Department of Pediatric Cardiology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan) ,  Okuma Yoshiaki (Department of Pediatrics, National Center for Global Health and Medicine, Tokyo, Japan) ,  Takada Nobuyuki (Department of Pediatrics, Kimitsu Chuo Hospital, Chiba, Japan) ,  Yanai Masaaki (Department of Pediatrics, Kumamoto Regional Medical Center, Kumamoto, Japan) ,  Sato Junichi (Department of Pediatrics, Funabashi Municipal Medical Center, Funabashi, Japan) ,  Nakayashiro Mami (Department of Pediatric Cardiology, Okinawa Prefectural Nanbu Medical Center and Children’s Medical Center, Okinawa, Japan) ,  Ayusawa Mamoru (Department of Pediatrics, Nihon University Itabashi Hospital, Tokyo, Japan) ,  Yamamoto Eiichi (Department of Pediatrics, Ehime Prefectural Central Hospital, Ehime, Japan) ,  Nomura Yuichi (Department of Pediatrics, Kagoshima City Hospital, Kagoshima, Japan) ,  Hashimura Yuya (Department of Pediatrics, Takatsuki General Hospital, Osaka, Japan) ,  Ouchi Kazunobu (Department of Pediatrics, Kawasaki Medical School Hospital, Okayama, Japan) ,  Masuda Hiroshi (Department of General Pediatrics & Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan) ,  Takatsuki Shinichi (Department of Pediatrics, Toho University, Tokyo, Japan) ,  Hirono Keiichi (Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan) ,  Ariga Tadashi (Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan) ,  Higaki Takashi (Department of Regional Pediatrics and Perinatology, Graduate School of Medicine, Ehime University, Ehime, Japan) ,  Otsuki Akio (Department of Pediatrics, Komatsu Municipal Hospital, Ishikawa, Japan) ,  Terauchi Moe (Clinical Research Centre, Chiba University Hospital, Chiba, Japan) ,  Aoyagi Reiko (Clinical Research Centre, Chiba University Hospital, Chiba, Japan) ,  Sato Takatoshi (Department of Pediatrics, Funabashi Municipal Medical Center, Funabashi, Japan) ,  Sato Takatoshi (Clinical Research Centre, Chiba University Hospital, Chiba, Japan) ,  Fujii Yasuhisa (Clinical Research Centre, Chiba University Hospital, Chiba, Japan) ,  Fujiwara Tadami (Clinical Research Centre, Chiba University Hospital, Chiba, Japan) ,  Hanaoka Hideki (Clinical Research Centre, Chiba University Hospital, Chiba, Japan) ,  Hata Akira (Department of Public Health, Chiba University, Chiba, Japan)
Material： Lancet
Volume： 393  Issue： 10176  Page： 1128-1137  Publication year： 2019 
JST Material Number： B0673A  ISSN： 0140-6736  CODEN： LANCA  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Genetic studies have indicated...

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Thesaurus term： *vein ,  *human ,  *phase 3 study ,  *therapy ,  *prevention ,  *Kawasaki disease ,  *effectiveness ,  pathogenesis ,  stratification ,  *coronary artery ,  *immunoglobulin ,  *end point ,  adverse reaction ,  polypeptide ,  cyclopeptide
Semi thesaurus term： 転帰 ,  有害事象 ,  *第一選択療法 , 【Automatic Indexing@JST】

JST classification (2)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Treatment for mental disorders in general  (GR04010S)

Substance index (1)： Ciclosporin

Terms in the title (16)： 静脈 ,  免疫グロブリン ,  リスク ,  予測 ,  川崎病 ,  患者 ,  冠動脈 ,  予防 ,  シクロスポリン ,  一次治療 ,  有効性 ,  対照 ,  ラベル ,  盲 ,  エンドポイント ,  第3相試験