Art

J-GLOBAL ID：201902235186771071   Reference number：19A0418294

Add-on tocilizumab versus conventional treatment for systemic sclerosis, and cytokine analysis to identify an endotype to tocilizumab therapy

全身性硬化症に対するアドオントシリズマブ対従来の治療,およびトシリズマブ療法へのエンド型を特定するためのサイトカイン分析

Author (3)： SHIMA Yoshihito (Osaka Univ. Graduate School of Medicine, Osaka, JPN) ,  KAWAGUCHI Yasushi (Tokyo Women’s Medical Univ., Tokyo, JPN) ,  KUWANA Masataka (Nippon Medical School Graduate School of Medicine, Tokyo, JPN)
Material： Modern Rheumatology  (Mod Rheumatol)
Volume： 29  Issue： 1  Page： 134-139  Publication year： Jan. 2019 
JST Material Number： L5142A  ISSN： 1439-7595  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *systemic scleroderma ,...

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JST classification (2)： Clinical application of anti-inflammatory drugs  (GW15020E) ,  Treatment for cryptogenic diseases,other diseases  (GD07030T)

Reference (25)：

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• Feghali CA, Bost KL, Boulware DW, Levy LS. Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma. J Rheumatol. 1992;19:1207-11.
• Sato S, Hasegawa M, Takehara K. Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis. J Dermatol Sci. 2001;27:140-6.
• Kawaguchi Y, Hara M, Wright TM. Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A. J Clin Invest. 1999;103:1253-60.
• Kitaba S, Murota H, Terao M, Azukizawa H, Terabe F, Shima Y, et al. Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma. Am J Pathol. 2012;180:165-76.

Terms in the title (6)： 全身性硬化症 ,  治療 ,  トシリズマブ ,  療法 ,  サイトカイン ,  分析