Art

J-GLOBAL ID：201902238012503891   Reference number：19A1406294

糖尿病治療薬5-アミノレブリン酸(ALA)によるアンチエイジング作用の可能性

Author (2)： NAKAJIMA OSAMU (山形大 大学院医学系研究科 先進的医科学専攻 遺伝情報解析学) ,  NAKAJIMA OSAMU (山形大 医 メディカルサイエンス推進研 遺伝子実験セ)
Material： 日本マススクリーニング学会誌  (日本マス・スクリーニング学会誌)
Volume： 29  Issue： 1  Page： 9-20  Publication year： May. 01, 2019 
JST Material Number： L3053A  ISSN： 0917-3803  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human ,...
Semi thesaurus term： *cell physiology ,...

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JST classification (2)： Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (3)： δ-Aminolevulinic acid ,  Sodium ferrous citrate ,  5-Aminolevulinic acid phosphate

Reference (17)：

• Higashikawa F, Noda M, Awaya T, Tanaka T, Sugiyama M: 5-aminolevulinic acid, a precursor of heme, reduces both fasting and postprandial glucose levels in mildly hyperglycemic subjects. Nutrition 29: 1030-1036, 2013.
• Rodriguez BL, Curb J, Davis J, Shintani T, Perez MH, Apau-Ludlum N, Johnson C and Harrigan RC: Use of the Dietary Supplement 5-Aminiolevulinic Acid (5-ALA) and Its Relationship with Glucose Levels and Hemoglobin A1C among Individuals with Prediabetes. Clin Translation Sci 5: 314-320, 2012.
• Yamashita N, Watanabe A, Kondo H, Kawata S, Tanaka T, Nakajima M: Safety test of a supplement, 5-aminolevulinic acid phosphate with sodium ferrous citrate, in diabetic patients treated with oral hypoglycemic agents. Func Foods Heal Dis 4: 415-428, 2014.
• Al-Saber F, Aldosari W, Alselaiti M, Khalfan H, Kaladari A, Khan G, George Harb, Rehani R, Kudo S, Koda A, Tanaka T, Nakajima M, Darwish A: The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain. J Diabetes Res Article ID 8294805, 10 pages, 2016.
• Okano S, Zhou L, Kusaka T, Shibata K, Shimizu K, Gao X, Kikuchi Y, Togashi Y, Hosoya T, Takahashi S, Nakajima O, Yamamoto M: Indispensable function for embryogenesis, expression and regulation of the nonspecific form of the 5-aminolevulinate synthase gene in mouse. Genes Cells, 15: 77-89, 2010.

Terms in the title (4)： 糖尿病治療薬 ,  5-アミノレブリン酸 ,  アンチエイジング ,  可能性