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J-GLOBAL ID：201902238574023329   Reference number：19A1549810

Efficacy of Valganciclovir Treatment Depends on the Severity of Hearing Dysfunction in Symptomatic Infants with Congenital Cytomegalovirus Infection

先天性Cytomegalovirus感染症の症候性乳児における聴力機能障害の重症度に依存するバルガン治療の有効性【JST・京大機械翻訳】

Author (15)： Ohyama Shohei (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Morioka Ichiro (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Morioka Ichiro (Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 173-8610, Japan) ,  Fukushima Sachiyo (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Yamana Keiji (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Nishida Kosuke (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Iwatani Sota (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Fujioka Kazumichi (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Matsumoto Hisayuki (Departments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan) ,  Imanishi Takamitsu (Departments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan) ,  Nakamachi Yuji (Departments of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan) ,  Deguchi Masashi (Departments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Tanimura Kenji (Departments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Iijima Kazumoto (Departments of Pediatrics, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan) ,  Yamada Hideto (Departments of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 20  Issue： 6  Page： 1388  Publication year： 2019 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 短報  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Although earlier studies have ...

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Thesaurus term： *Infant ,  *effectiveness ,  pretreatment ,  viral disease ,  *auditory acuity ,  *infectious disease ,  *dysfunction ,  prospective cohort study ,  *therapy ,  human ,  auditory sense ,  Cytomegalovirus ,  *child ,  microorganism ,  Herpesviridae
Semi thesaurus term： サイトメガロウイルス感染症 ,  レジメン ,  *重症度 ,  *Cytomegalovirus , 【Automatic Indexing@JST】

Author keywords (5)： auditory brainstem response ,  congenital cytomegalovirus infection ,  hearing dysfunction ,  severity ,  valganciclovir

JST classification (1)： Basic neurology  (GN01020W)

Reference (19)：

• Morton, C.C.; Nance, W.E. Newborn hearing screening-A silent revolution. N. Engl. J. Med. 2006, 354, 2151-2164.
• Kimberlin, D.W.; Lin, C.Y.; Sanchez, P.J.; Demmler, G.J.; Dankner, W.; Shelton, M.; Jacobs, R.F.; Vaudr, W.; Pass, R.F.; Kiell, J.M.; et al. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: A randomized, controlled trial. J. Pediatr. 2003, 143, 16-25.
• Amir, J.; Wolf, D.G.; Levy, I. Treatment of symptomatic congenital cytomegalovirus infection with intravenous ganciclovir followed by long-term oral valganciclovir. Eur. J. Pediatr. 2010, 169, 1061-1067.
• Kimberlin, D.W.; Jester, P.M.; Sanchez, P.J.; Ahmed, A.; Arav-Boger, R.; Michaels, M.G.; Ashouri, N.; Englund, J.A.; Estrada, B.; Jacobs, R.F.; et al. Valganciclovir for symptomatic congenital cytomegalovirus disease. N. Engl. J. Med. 2015, 372, 933-943.
• Bilavsky, E.; Shahar-Nissan, K.; Pardo, J.; Attias, J.; Amir, J. Hearing outcome of infants with congenital cytomegalovirus and hearing impairment. Arch. Dis. Child. 2016, 101, 433-438.

Terms in the title (10)： Cytomegalovirus ,  感染症 ,  症候 ,  乳児 ,  聴力 ,  機能障害 ,  重症度 ,  バル ,  ガン治療 ,  有効性