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J-GLOBAL ID：201902238867026923   Reference number：19A1946746

Ataxic phenotype with altered Ca_V3.1 channel property in a mouse model for spinocerebellar ataxia 42

脊髄小脳性運動失調42のマウスモデルにおける変化したCa_v3.1チャンネル特性を伴う運動失調表現型【JST・京大機械翻訳】

Author (39)： Hashiguchi Shunta (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Doi Hiroshi (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Kunii Misako (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Nakamura Yukihiro (Department of Pharmacology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan) ,  Shimuta Misa (Department of Pharmacology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan) ,  Suzuki Etsuko (Department of Pharmacology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan) ,  Koyano Shigeru (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Okubo Masaki (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Kishida Hitaru (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Shiina Masaaki (Department of Biochemistry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Ogata Kazuhiro (Department of Biochemistry, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Hirashima Fumiko (Department of Rehabilitation Medicine, Flower and Forest Tokyo Hospital, 2-3-6 Nishigahara, Kita-ku, Tokyo 114-0024, Japan) ,  Inoue Yukichi (Department of Neurology, Toyama Prefectural Rehabilitation Hospital and Support Center for Children with Disabilities, 36 Shimoiino, Toyama 931-8517, Japan) ,  Kubota Shun (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Hayashi Noriko (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Nakamura Haruko (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Takahashi Keita (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Katsumoto Atsuko (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Tada Mikiko (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Tanaka Kenichi (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Sasaoka Toshikuni (Department of Comparative and Experimental Medicine, Center for Bioresource-based Researches, Brain Research Institute, Niigata University, 1-757 Asahimachidori, Chuo-ku, Niigata 951-8585, Japan) ,  Miyatake Satoko (Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Miyake Noriko (Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Saitsu Hirotomo (Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Sato Nozomu (Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-0034, Japan) ,  Ozaki Kokoro (Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-0034, Japan) ,  Ohta Kiyobumi (Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-0034, Japan) ,  Yokota Takanori (Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-0034, Japan) ,  Mizusawa Hidehiro (Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-0034, Japan) ,  Mitsui Jun (Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan) ,  Ishiura Hiroyuki (Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan) ,  Yoshimura Jun (Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan) ,  Morishita Shinichi (Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan) ,  Tsuji Shoji (Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan) ,  Takeuchi Hideyuki (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Ishikawa Kinya (Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-0034, Japan) ,  Matsumoto Naomichi (Department of Human Genetics, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan) ,  Ishikawa Taro (Department of Pharmacology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan) ,  Tanaka Fumiaki (Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan)
Material： Neurobiology of Disease  (Neurobiol Dis)
Volume： 130  Page： Null  Publication year： 2019 
JST Material Number： W1774A  ISSN： 0969-9961  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Spinocerebellar ataxia 42 (SCA...

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Thesaurus term： *Mus musculus ,  hyperpolarization ,  *Phenotype ,  Point Mutation ,  human ,  Purkinje Cells ,  *Cerebellum ,  *Ataxia ,  Mutation ,  *channel ,  ubiquitin ,  atrophy (disease) ,  Synaptic Transmission ,  *mouse model ,  Genetic Variation ,  *Myomorpha ,  *Brain
Semi thesaurus term： variation(biology) ,  神経変性 , 【Automatic Indexing@JST】

Author keywords (8)： Cerebellum ,  Spinocerebellar ataxia 42 ,  CACNA1G ,  Knock-in mouse ,  Purkinje cell ,  Inferior olivary nucleus ,  Neurodegeneration ,  Electrophysiology

JST classification (2)： Congenital diseases,deformities in general.  (GD03010V) ,  Basic neurology  (GN01020W)

Terms in the title (5)： 脊髄小脳性運動失調 ,  マウスモデル ,  チャンネル ,  運動失調 ,  表現型