Art

J-GLOBAL ID：201902241641409067   Reference number：19A2027066

Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats

ベンズブロマロンはアンギオテンシンIIおよび食塩誘発高血圧モデルラットにおける酸化ストレスを軽減する【JST・京大機械翻訳】

Author (20)： Muraya Nanako (Department of Clinical Pharmacology, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Kadowaki Daisuke (Department of Clinical Pharmacology, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Kadowaki Daisuke (Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Kadowaki Daisuke (Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan) ,  Kadowaki Daisuke (DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan) ,  Miyamura Shigeyuki (Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan) ,  Kitamura Kenichiro (Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan) ,  Uchimura Kohei (Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan) ,  Narita Yuki (Department of Clinical Pharmacology, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Narita Yuki (Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Miyamoto Yohei (Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan) ,  Chuang Victor Tuan Giam (School of Pharmacy, Monash University Malaysia, Level 5, Building 2, Malaysia Campus, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia) ,  Taguchi Kazuaki (DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan) ,  Taguchi Kazuaki (Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan) ,  Maruyama Toru (Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Maruyama Toru (Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan) ,  Otagiri Masaki (DDS Research Institute, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan) ,  Otagiri Masaki (Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan) ,  Hirata Sumio (Department of Clinical Pharmacology, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan) ,  Hirata Sumio (Center for Clinical Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1, Oe-Honmachi, Chuo-ku, Kumamoto 862-0973, Japan)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2018  Page： Null  Publication year： 2018 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Oxidative stress induced by hy...

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Thesaurus term： Plasma ,  *Hypertension ,  *sodium chloride (dietary) ,  Chronic kidney disease ,  *oxidation ,  in vitro experiment ,  Proteins ,  *Angiotensin II ,  *Blood Pressure ,  antioxidation ,  *oxidative stress ,  oral administration ,  modeling ,  nitrogen heterocyclic compound ,  urea compound ,  hydroxy compound ,  aromatic ketone ,  phenolic compound ,  oxygen heterocyclic compound ,  aromatic bromine compound ,  polynuclear aromatic compound ,  hydroxy ketone

JST classification (1)： Basic research of pharmacology of crude drugs  (GX06020J)

Substance index (2)： Uric Acid ,  Benzbromarone

Reference (33)：

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• T. K. Ma, K. K. Kam, B. P. Yan, Y. Y. Lam, "Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status," British Journal of Pharmacology, vol. 160, no. 6, pp. 1273-1292, 2010.
• A. Sirker, M. Zhang, C. Murdoch, A. M. Shah, "Involvement of NADPH oxidases in cardiac remodelling and heart failure," American Journal of Nephrology, vol. 27, no. 6, pp. 649-660, 2007.
• K. K. Griendling, C. A. Minieri, J. D. Ollerenshaw, R. W. Alexander, "Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells," Circulation Research, vol. 74, no. 6, pp. 1141-1148, 1994.
• R. M. Touyz, "Oxidative stress and vascular damage in hypertension," Current Hypertension Reports, vol. 2, no. 1, pp. 98-105, 2000.

Terms in the title (7)： ベンズブロマロン ,  アンギオテンシンII ,  食塩 ,  誘発 ,  血圧 ,  モデルラット ,  酸化ストレス