Art

J-GLOBAL ID：201902242721122302   Reference number：19A2685573

核酸創薬を目指す化学ケージド型核酸の開発

Author (1)： IKEDA MASATO (岐阜大 工)
Material： 第一三共生命科学研究振興財団研究報告集
Volume： 35  Page： 14-18  Publication year： Oct. 31, 2019 
JST Material Number： L2409A  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *bioactive factor ,  nucleic acid ,  product development ,  *chemical stimulation ,  *artificial nucleic acid ,  *response ,  group (radical) ,  *steric conformation ,  *DNA ,  *RNA nucleotidyltransferase ,  *on-off control ,  reduction (reaction) ,  OR circuit ,  AND circuit ,  alkyl(aryl) transferase ,  sodium compound ,  dithionite ,  *DNA aptamer ,  alkylguanine DNA alkyltransferase ,  *caged compound ,  oxygen reduction ,  Drug Discovery ,  *DNA, Catalytic ,  sodium dithionite ,  *G-Quadruplexes ,  *stimulus-response
Semi thesaurus term： AND gate ,  *DNAzyme ,  Na2S2O4 ,  *guanine quartet ,  ニトロベンジル基 ,  OR gate ,  reduction (reaction) ,  *stimuli-responsivity

JST classification (3)： Nucleosides,nucleotides  (CF10060K) ,  Stereochemistry of polymers  (CG02031G) ,  Reaction of polymers in general  (CG03001G)

Reference (6)：

• Liu Q. and Deiters A. : Optochemical control of deoxyoligonucleotide function via a nucleobase-caging approach. Acc. Chem. Res., 47 : 45-55, 2014.
• Ikeda M. and Kabumoto M. : Chemically caged nucleic acids. Chem. Lett., 46 : 634-640, 2017.
• Ikeda M., Tanida T., Yoshii T. and Hamachi I. : Rational molecular design of stimulus-responsive supramolecular hydrogel based on dipeptides. Adv. Mater., 23 : 2819-2822, 2011.
• Ikeda M., Kamimura M., Hayakawa Y., Shibata A. and Kitade Y. : Reduction responsive guanine incorporated into G-quadruplex forming DNA. ChemBioChem, 17 : 1304-1307, 2016.
• Hayakawa Y., Banno A., Kitagawa H., Higashi S., Kitade Y., Shibata A. and Ikeda M. : Reduction-responsive DNA duplex containing O⁶-nitrobenzyl-guanine. ACS Omega, 3 : 9267-9275, 2018.

Terms in the title (4)： 核酸 ,  創薬 ,  化学 ,  開発