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J-GLOBAL ID：201902242855789224   Reference number：19A0865106

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands

低分子量CXCR4リガンドの設計,合成および生物学的評価【JST・京大機械翻訳】

Author (12)： Sakyiamah Maxwell M. (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Sakyiamah Maxwell M. (Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8150, Japan) ,  Kobayakawa Takuya (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Fujino Masayuki (AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Konno Makoto (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Narumi Tetsuo (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Tanaka Tomohiro (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Nomura Wataru (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Yamamoto Naoki (Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore) ,  Murakami Tsutomu (AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan) ,  Tamamura Hirokazu (Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan) ,  Tamamura Hirokazu (Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8150, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 27  Issue： 6  Page： 1130-1138  Publication year： 2019 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： The chemokine receptor CXCR4/s...

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Thesaurus term： cation ,  Chemokine Receptors ,  *Lead ,  probe ,  HIV ,  interaction ,  rheumatoid arthritis ,  amino acid residue ,  spacer ,  effect concentration 50 ,  binding affinity ,  *Receptors, CXCR4 ,  Signal Transduction ,  Anti-HIV activity ,  microorganism ,  animal virus ,  macrocyclic compound ,  nitrogen heterocyclic compound
Semi thesaurus term： cellular signal transduction ,  抗HIV活性 , 【Automatic Indexing@JST】

Author keywords (5)： Anti-HIV ,  Azamacrocyclic compound ,  CXCR4-binding ,  Dipicolylamine ,  NanoBRET assay

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Receptors on cell membrane  (EF04030C)

Substance index (1)： Cyclam

Terms in the title (5)： 低分子量 ,  CXCR4 ,  リガンド ,  設計 ,  生物学的評価