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J-GLOBAL ID：201902243777345449   Reference number：19A0338086

ELKS/Voltage-Dependent Ca²⁺ Channel-β Subunit Module Regulates Polarized Ca²⁺ Influx in Pancreatic β Cells

ElkS/電位依存性Ca2+チャンネル-βサブユニットモジュールは膵臓β細胞における分極Ca2+流入を調節する【JST・京大機械翻訳】

Author (25)： Ohara-Imaizumi Mica (Department of Biochemistry, Kyorin University School of Medicine, Tokyo 181-8611, Japan) ,  Aoyagi Kyota (Department of Biochemistry, Kyorin University School of Medicine, Tokyo 181-8611, Japan) ,  Yamauchi Hajime (Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan) ,  Yoshida Masashi (First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama 337-8503, Japan) ,  Mori Masayuki X. (Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan) ,  Hida Yamato (Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan) ,  Tran Ha Nam (Department of Technology and Ecology, Hall of Global Environmental Studies, Kyoto University, Kyoto 615-8510, Japan) ,  Ohkura Masamichi (Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan) ,  Ohkura Masamichi (Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan) ,  Abe Manabu (Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Abe Manabu (Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Akimoto Yoshihiro (Department of Anatomy, Kyorin University School of Medicine, Tokyo 181-8611, Japan) ,  Nakamichi Yoko (Department of Biochemistry, Kyorin University School of Medicine, Tokyo 181-8611, Japan) ,  Nishiwaki Chiyono (Department of Biochemistry, Kyorin University School of Medicine, Tokyo 181-8611, Japan) ,  Kawakami Hayato (Department of Anatomy, Kyorin University School of Medicine, Tokyo 181-8611, Japan) ,  Hara Kazuo (First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama 337-8503, Japan) ,  Sakimura Kenji (Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan) ,  Nagamatsu Shinya (Department of Biochemistry, Kyorin University School of Medicine, Tokyo 181-8611, Japan) ,  Nagamatsu Shinya (Shinei-Diabetic-Clinic, Tokyo 166-0003, Japan) ,  Mori Yasuo (Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan) ,  Mori Yasuo (Department of Technology and Ecology, Hall of Global Environmental Studies, Kyoto University, Kyoto 615-8510, Japan) ,  Nakai Junichi (Graduate School of Science and Engineering, Saitama University, Saitama 338-8570, Japan) ,  Nakai Junichi (Brain and Body System Science Institute, Saitama University, Saitama 338-8570, Japan) ,  Kakei Masafumi (First Department of Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama 337-8503, Japan) ,  Ohtsuka Toshihisa (Department of Biochemistry, Graduate School of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan)
Material： Cell Reports
Volume： 26  Issue： 5  Page： 1213-1226.e7  Publication year： 2019 
JST Material Number： W3124A  ISSN： 2211-1247  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Pancreatic β cells secrete ins...

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Thesaurus term： Mus musculus ,  image processing ,  neuron ,  sensor ,  interaction ,  Cell Membrane ,  *Calcium Channels ,  Exocytosis ,  complex (substance) ,  insulin ,  Islets of Langerhans ,  secretion (physiology) ,  *polarization (phenomenon) ,  insulin secretion ,  Myomorpha ,  Endomembrane system ,  *Ion Transport ,  *transportation ,  *Biological Transport ,  *transmembrane protein ,  *ion transport(in vivo) ,  hypoglycemic drug ,  metabolic drug ,  carbohydrate metabolic drug ,  drug ,  hexose ,  aldose

Author keywords (6)： pancreatic β cells ,  ELKS ,  active zone protein ,  voltage-dependent Ca²⁺ channel ,  insulin exocytosis ,  Ca²⁺ influx

JST classification (3)： Transport of cell membrane  (EF04020R) ,  Pancreatic hormones  (EB08020H) ,  Pancreas  (EJ06050Y)

Substance index (1)： Glucose

Terms in the title (8)： 電位依存性 ,  Ca2+チャンネル ,  βサブユニット ,  モジュール ,  膵臓β細胞 ,  分極 ,  Ca2+流入 ,  調節