Art

J-GLOBAL ID：201902249398072769   Reference number：19A0996950

Virtual screening identification of novel chemical inhibitors for aberrant interactions between pathogenic mutant SOD1 and tubulin

病原性変異体SOD1とチューブリン間の異常相互作用のための新規化学阻害剤の仮想スクリーニング同定【JST・京大機械翻訳】

Author (6)： Hirayama Kazunori (Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan) ,  Fujiwara Yuuki (Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan) ,  Terada Tohru (Interfaculty Initiative in Information Studies, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan) ,  Shimizu Kentaro (Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan) ,  Wada Keiji (Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan) ,  Kabuta Tomohiro (Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8502, Japan)
Material： Neurochemistry International  (Neurochem Int)
Volume： 126  Page： 19-26  Publication year： 2019 
JST Material Number： E0890A  ISSN： 0197-0186  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Amyotrophic lateral sclerosis ...

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Thesaurus term： in vitro experiment ,  toxicity ,  death ,  superoxide dismutase ,  *interaction ,  *variation(biology) ,  gene ,  pathogenesis ,  human(primates) ,  *tubulin ,  binding site ,  *screening(inspection) ,  mutation ,  therapy
Semi thesaurus term： 残基 ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： Virtual screening ,  ALS ,  Mutant SOD1 ,  Tubulin ,  Protein-protein interaction

JST classification (4)： Gene expression  (EC02040Q) ,  Basic neurology  (GN01020W) ,  Biological function  (EB03040U) ,  Enzyme in general  (EB09010D)

Terms in the title (9)： 病原性 ,  変異体 ,  SOD1 ,  チューブリン ,  相互作用 ,  化学 ,  阻害剤 ,  仮想スクリーニング ,  同定