Art

J-GLOBAL ID：201902250311315880   Reference number：19A2733734

4-(Hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronide has the potential to form 2’-deoxyguanosine and N-acetylcysteine adducts

4-(ヒドロキシメチルニトロサミノ)-1-(3-ピリジル)-1-ブタノングルクロニドは2′-デオキシグアノシンとN-アセチルシステイン付加物を形成する可能性がある

Author (6)： Nishiyama Takahito (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Hayashi Nahoko (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Yanagita Hiromi (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Ohnuma Tomokazu (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Ogura Kenichiro (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Hiratsuka Akira (Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 44  Issue： 10  Page： 693-699(J-STAGE)  Publication year： 2019 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： tobacco (favorite) ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A2733734&from=J-GLOBAL&jstjournalNo=Z0265B") }}

Author keywords (6)： N-Acetylcysteine ,  2’-Deoxyguanosine ,  Glucuronide ,  NNK ,  Reactive intermediate ,  Target organs

JST classification (2)： Toxicity of organic compounds  (GZ02030Y) ,  Carcinogenic mechanisms and factors  (GE02020C)

Substance index (5)： Deoxyguanosine ,  HO-Methyl NNK ,  NNK ,  Acetylcysteine ,  OH-Methyl NNK glucuronide

Reference (13)：

• Alguacil, J., Kogevinas, M., Silverman, D.T., Malats, N., Real, F.X., García-Closas, M., Tardón, A., Rivas, M., Torà, M., García-Closas, R., Serra, C., Carrato, A., Pfeiffer, R.M., Fortuny, J., Samanic, C. and Rothman, N. (2011): Urinary pH, cigarette smoking and bladder cancer risk. Carcinogenesis, 32, 843-847.
• Carmella, S.G., Kagan, S.S., Spratt, T.E. and Hecht, S.S. (1990): Evaluation of cysteine adduct formation in rat hemoglobin by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and related compounds. Cancer Res., 50, 5453-5459.
• Hecht, S.S., Lin, D., Chuand, J. and Castonguay, A. (1986): Reactions with deoxyguanosine of 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, a model compound for a-hydroxylation of tabacco-specific nitrosamines. J. Am. Chem. Soc., 108, 1292-1295.
• Hecht, S.S. (1998): Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem. Res. Toxicol., 11, 559-603.
• Hecht, S.S., Trushin, N., Reid-Quinn, C.A., Burak, E.S., Jones, A.B., Southers, J.L., Gombar, C.T., Carmella, S.G., Anderson, L.M. and Rice, J.M. (1993): Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites. Carcinogenesis, 14, 229-236.

Terms in the title (7)： ピリジル ,  1-ブタノン ,  グルクロニド ,  2′-デオキシグアノシン ,  N-アセチルシステイン ,  付加物 ,  可能性