Art

J-GLOBAL ID：201902251195019297   Reference number：19A0610650

Augmentation of Lipopolysaccharide-Induced Production of IL-1α and IL-1β in Mice Given Intravenous Zoledronate (a Nitrogen-Containing Bisphosphonate) and Its Prevention by Clodronate (a Non-nitrogen-containing Bisphosphonate)

静脈内ゾレドロン酸(窒素含有ビスホスホネート)を投与したマウスにおけるリポ多糖類誘発IL-1αおよびIL-1β産生の増加とクロドロン酸(非窒素含有ビスホスホネート)によるその予防

Author (9)： Suzuki Hikari (Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University) ,  Bando Kanan (Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Tohoku University) ,  Tada Hiroyuki (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Kiyama Tomomi (Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University) ,  Oizumi Takefumi (Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University) ,  Funayama Hiromi (Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine) ,  Sugawara Shunji (Division of Oral Molecular Regulation, Graduate School of Dentistry, Tohoku University) ,  Takahashi Tetsu (Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University) ,  Endo Yasuo (Division of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 2  Page： 164-172(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： immunological reaction ,...

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Author keywords (12)： bisphosphonate ,  zoledronate ,  clodronate ,  interleukin-1 (IL-1) ,  lipopolysaccharide (LPS) ,  side effect ,  bisphosphonate ,  zoledronate ,  clodronate ,  interleukin-1 (IL-1) ,  lipopolysaccharide (LPS) ,  side effect

JST classification (1)： Basic research of other drugs acting on metabolism  (GW13060I)

Substance index (2)： Clodronate ,  Zoledronate

Reference (44)：

• 1) Fleisch H. Diphosphonates: history and mechanisms of actions. Metab. Bone Dis. Relat. Res., 3, 279-287 (1981).
• 2) Rogers MJ, Crockett JC, Coxon FP, Mönkkönen J. Biochemical and molecular mechanisms of action of bisphosphonates. Bone, 49, 34-41 (2011).
• 3) Endo Y, Kumamoto H, Nakamura M, Sugawara S, Takano-Yamamoto T, Sasaki K, Takahashi T. Underlying mechanisms and therapeutic strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ). Biol. Pharm. Bull., 40, 739-750 (2017).
• 4) Geddes AD, D’Souza SM, Ebetino FH, Kenneth JI. Bisphosphonates: structure-activity relationships and therapeutic implications. Bone and Mineral Research. (Heershe NM, Kanis JK ed). Vol. 8, Elsevier Science BV, Amsterdam, Holland, pp. 265-306 (1994).
• 5) Adami S, Bhalla AK, Dorizzi R, Montesanti F, Rosini S, Salvagno G, Lo Cascio V. The acute phase response after bisphosphonate administration. Calcif. Tissue Int., 41, 326-331 (1987).

Terms in the title (12)： 静脈 ,  ゾレドロン酸 ,  窒素 ,  ビスホスホネート ,  投与 ,  マウス ,  リポ多糖類 ,  誘発 ,  IL-1 ,  IL-1β ,  クロドロン酸 ,  予防