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J-GLOBAL ID：201902251242405878   Reference number：19A2328227

Preparation of Lipid Nanodisks Containing Apolipoprotein E-Derived Synthetic Peptides for Biocompatible Delivery Vehicles Targeting Low-Density Lipoprotein Receptor

低密度リポ蛋白質受容体を標的とする生体適合性デリバリー輸送体のためのアポリポ蛋白質E由来合成ペプチド含有脂質ナノディスクの調製

Author (6)： Tanaka Masafumi (Laboratory of Biophysical Chemistry, Kobe Pharmaceutical University) ,  Tanaka Masafumi (Laboratory of Functional Molecular Chemistry, Kobe Pharmaceutical University) ,  Hasegawa Mariko (Laboratory of Biophysical Chemistry, Kobe Pharmaceutical University) ,  Yoshimoto Natsumi (Laboratory of Biophysical Chemistry, Kobe Pharmaceutical University) ,  Hoshikawa Kozue (Laboratory of Biophysical Chemistry, Kobe Pharmaceutical University) ,  Mukai Takahiro (Laboratory of Biophysical Chemistry, Kobe Pharmaceutical University)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 42  Issue： 8  Page： 1376-1383(J-STAGE)  Publication year： 2019 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *drug delivery system ,...
Semi thesaurus term： *nanodisk

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Author keywords (10)： lipid nanodisk ,  apolipoprotein E ,  high-density lipoprotein ,  low-density lipoprotein receptor ,  delivery vehicle ,  lipid nanodisk ,  apolipoprotein E ,  high-density lipoprotein ,  low-density lipoprotein receptor ,  delivery vehicle

JST classification (1)： Physicochemical pharmacy in general  (GV01010J)

Reference (44)：

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• 2) Pownall HJ, Massey JB, Kusserow SK, Gotto AM Jr. Kinetics of lipid-protein interactions: interaction of apolipoprotein A-I from human plasma high density lipoproteins with phosphatidylcholines. Biochemistry, 17, 1183-1188 (1978).
• 3) Segall ML, Dhanasekaran P, Baldwin F, Anantharamaiah GM, Weisgraber KH, Phillips MC, Lund-Katz S. Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization. J. Lipid Res., 43, 1688-1700 (2002).
• 4) Papahadjopoulos D, Allen TM, Gabizon A, Mayhew E, Matthay K, Huang SK, Lee KD, Woodle MC, Lasic DD, Redemann C. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. U.S.A., 88, 11460-11464 (1991).
• 5) Bricarello DA, Smilowitz JT, Zivkovic AM, German JB, Parikh AN. Reconstituted lipoprotein: a versatile class of biologically-inspired nanostructures. ACS Nano, 5, 42-57 (2011).

Terms in the title (10)： 低密度リポ蛋白質受容体 ,  標的 ,  生体適合性 ,  デリバリー ,  輸送 ,  アポリポ蛋白質E ,  合成ペプチド ,  脂質 ,  ナノディスク ,  調製