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J-GLOBAL ID：201902251838804578   Reference number：19A0881377

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

ヒトβ-グルコセレブロシダーゼに対するSP2-イミノ糖の阻害剤対シャペロン特性の探索:ゴーシェ病のためのピコモルシャペロン【JST・京大機械翻訳】

Author (10)： Mena-Barragan Teresa (Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, C/Profesor Garcia Gonzalez 1, 41011 Sevilla, Spain) ,  Garcia-Moreno M. Isabel (Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, C/Profesor Garcia Gonzalez 1, 41011 Sevilla, Spain) ,  Sevsek Alen (Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands) ,  Okazaki Tetsuya (Division of Child Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago 680-8550, Japan) ,  Nanba Eiji (Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan) ,  Higaki Katsumi (Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, 86 Nishi-cho, Yonago 683-8503, Japan) ,  Martin Nathaniel I. (Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands) ,  Pieters Roland J. (Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands) ,  Fernandez Jose M. Garcia (Instituto de Investigaciones Quimicas (IIQ), CSIC-University of Sevilla, Avda. Americo Vespucio 49, 41092 Sevilla, Spain) ,  Mellet Carmen Ortiz (Department of Organic Chemistry, Faculty of Chemistry, University of Sevilla, C/Profesor Garcia Gonzalez 1, 41011 Sevilla, Spain)
Material： Molecules (Web)
Volume： 23  Issue： 4  Page： 927  Publication year： 2018 
JST Material Number： U7014A  ISSN： 1420-3049  CODEN： MOLEFW  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： A series of sp2-iminosugar gly...

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Thesaurus term： *chaperone protein ,  *Gaucher Disease ,  hydroxylation ,  affinity ,  glycosidic linkage hydrolase ,  *human ,  complex (substance) ,  neuropathy ,  inhibitor ,  complementation ,  fibroblast ,  glucosidase ,  *Glucosylceramidase ,  Genetic Variation
Semi thesaurus term： variation(biology) ,  *阻害剤 , 【Automatic Indexing@JST】

Author keywords (6)： sp²-Iminosugars ,  deoxynojirimycin ,  glycosidase inhibitors ,  glucocerebrosidase ,  chaperones ,  Gaucher disease

JST classification (5)： Plant biochemistry  (EH01050J) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Animal aquatic foods  (FJ13020C) ,  Enzyme in general  (EB09010D) ,  Influence on microorganisms  (EE05020V)

Reference (90)：

• Ernst, B.; Magnani, J.L. From carbohydrate leads to glycomimetic drugs. Nat. Rev. Drug Discov. 2009, 8, 661-677.
• Horne, G.; Wilson, F.X.; Tinsley, J.; Williams, D.H.; Storer, R. Iminosugars past, present and future: Medicines for tomorrow. Drug Discov. Today 2011, 16, 107-118.
• Nash, R.J.; Kato, A.; Yu, C.-Y.; Fleet, G.W.J. Iminosugars as therapeutic agents: Recent advances and promising trends. Future Med. Chem. 2011, 3, 1513-1521.
• Horne, G. Iminosugars: Therapeutic Applications and Synthetic Considerations. In Carbohydrate as Drugs, 1st ed.; Seeberger, P.H., Rademacher, C., Eds.; Topics in Medicinal Chemistry; Springer International Publishing: Basel, Switzerland, 2014; Volume 12, pp. 23-52. ISBN 978-3-319-08674-3.
• Campbell, L.K.; Baker, D.E.; Campbell, R.K. Miglitol: Assessment of its Role in the Treatment of Patients with Diabetes Mellitus. Ann. Pharmacother. 2000, 34, 1291-1301.

Terms in the title (7)： ヒト ,  グルコセレブロシダーゼ ,  イミノ糖 ,  阻害剤 ,  シャペロン ,  探索 ,  ゴーシェ病