Art

J-GLOBAL ID：201902252677654562   Reference number：19A2030819

Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death

インドール-3-プロピオン酸は化学シャペロン活性を有し小胞体ストレス誘導ニューロン細胞死を抑制する【JST・京大機械翻訳】

Author (8)： Mimori Seisuke (Department of Clinical Medicine, Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomicho, Choshi, Chiba, 288-0025, Japan) ,  Kawada Koichi (Department of Pharmacology, Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomicho, Choshi, Chiba, 288-0025, Japan) ,  Saito Ryo (Advanced Clinical Research Center, Southern Tohoku Research Institute for Neuroscience, 255 Furusawa-tsuko, Asao-ku, Kawasaki, Kanagawa, 215-0026, Japan) ,  Takahashi Masato (Laboratory of Drug Metabolism and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15-8 Shiomicho, Choshi, Chiba, 288-0025, Japan) ,  Mizoi Kenta (Department of Pharmacy, Faculty of Pharmacy, Takasaki University of Health and Welfare, 60, Nakaorui-machi, Takasaki, Gunma, 377-0033, Japan) ,  Okuma Yasunobu (Department of Pharmacology, Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomicho, Choshi, Chiba, 288-0025, Japan) ,  Hosokawa Masakiyo (Laboratory of Drug Metabolism and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15-8 Shiomicho, Choshi, Chiba, 288-0025, Japan) ,  Kanzaki Tetsuto (Department of Drug Informatics, Graduate School and Faculty of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8675, Japan)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 517  Issue： 4  Page： 623-628  Publication year： 2019 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Insoluble aggregated proteins ...

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Thesaurus term： optimization ,  *Endoplasmic Reticulum ,  cell culture ,  aggregation ,  amyloid beta-protein ,  therapy ,  Parkinson's disease ,  human ,  Proteins ,  *neuron ,  *Death ,  neuronal cell death ,  denatured protein ,  Neurodegenerative Diseases ,  modification ,  Amyloid ,  glycoprotein ,  animal protein
Semi thesaurus term： レジメン ,  *ケミカルシャペロン , 【Automatic Indexing@JST】

Author keywords (5)： Chemical chaperone ,  Indole-3-propionic acid ,  4-Phenyl butyric acid ,  Parkinson’s disease ,  Endoplasmic reticulum stress

JST classification (1)： Cell components in general  (EF03010Z)

Terms in the title (8)： インドール ,  プロピオン酸 ,  化学 ,  シャペロン活性 ,  小胞体ストレス ,  誘導 ,  ニューロン ,  細胞死